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Molecules 2012, 17(4), 4028-4036; doi:10.3390/molecules17044028
Article

Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis

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Received: 9 February 2012 / Revised: 27 March 2012 / Accepted: 28 March 2012 / Published: 2 April 2012
(This article belongs to the Section Metabolites)
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Abstract

A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90% relaxation at 1 × 10−5 M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90% relaxation at 1 × 10−5 M) on an isolated rat aorta.
Keywords: naucline; angustine; angustidine; nauclefine; naucletine; Rubiaceae; vasorelaxant activity naucline; angustine; angustidine; nauclefine; naucletine; Rubiaceae; vasorelaxant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liew, S.Y.; Mukhtar, M.R.; Hadi, A.H.A.; Awang, K.; Mustafa, M.R.; Zaima, K.; Morita, H.; Litaudon, M. Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis. Molecules 2012, 17, 4028-4036.

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