Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis†
AbstractA new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90% relaxation at 1 × 10−5 M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90% relaxation at 1 × 10−5 M) on an isolated rat aorta.
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Liew, S.Y.; Mukhtar, M.R.; Hadi, A.H.A.; Awang, K.; Mustafa, M.R.; Zaima, K.; Morita, H.; Litaudon, M. Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis. Molecules 2012, 17, 4028-4036.
Liew SY, Mukhtar MR, Hadi AHA, Awang K, Mustafa MR, Zaima K, Morita H, Litaudon M. Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis. Molecules. 2012; 17(4):4028-4036.Chicago/Turabian Style
Liew, Sook Yee; Mukhtar, Mat Ropi; Hadi, A. Hamid A.; Awang, Khalijah; Mustafa, Mohd Rais; Zaima, Kazumasa; Morita, Hiroshi; Litaudon, Marc. 2012. "Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis." Molecules 17, no. 4: 4028-4036.