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• Zhang, M
• Abdukader, A
• Fu, Y
• Zhu, C
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• Zhang, M
• Abdukader, A
• Fu, Y
• Zhu, C
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• Zhang, M
• Abdukader, A
• Fu, Y
• Zhu, C

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Molecules 2012, 17(3), 2812-2822; doi:10.3390/molecules17032812

Communication

Efficient Synthesis of β-Enaminones and β-Enaminoesters Catalyzed by Gold (I)/Silver (I) under Solvent-Free Conditions

Ming Zhang ¹ , Ablimit Abdukader ^1,2 , Yong Fu ¹  and Chengjian Zhu ^1,3,*

¹ State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China ² School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China ³ State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

* Author to whom correspondence should be addressed.

Received: 15 January 2012; in revised form: 16 February 2012 / Accepted: 17 February 2012 / Published: 6 March 2012

(This article belongs to the Section Organic Synthesis)

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Abstract: An efficient method for the synthesis of β-enaminones and β-enaminoesters using a combination of [(PPh₃)AuCl]/AgOTf as catalyst has been developed. The reaction between 1,3-dicarbonyl compounds and primary amines was carried out under solvent-free conditions with low catalyst loading in good to excellent yields at room temperature.

Keywords: gold; solvent-free; amines; β-enaminones; β-enaminoesters

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