Molecules 2012, 17(3), 2704-2713; doi:10.3390/molecules17032704
Article

Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components

1,2email, 1,2email, 1,2email, 1,2,* email and 3email
1 Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, China 2 Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, China 3 Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz 55099, Germany
* Author to whom correspondence should be addressed.
Received: 9 January 2012; in revised form: 20 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012
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Abstract: In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC50) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations.
Keywords: Rosmarinus officinalis L.; 1,8-cineole; α-pinene; β-pinene; antibacterial activities; cytotoxicity

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MDPI and ACS Style

Wang, W.; Li, N.; Luo, M.; Zu, Y.; Efferth, T. Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components. Molecules 2012, 17, 2704-2713.

AMA Style

Wang W, Li N, Luo M, Zu Y, Efferth T. Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components. Molecules. 2012; 17(3):2704-2713.

Chicago/Turabian Style

Wang, Wei; Li, Nan; Luo, Meng; Zu, Yuangang; Efferth, Thomas. 2012. "Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components." Molecules 17, no. 3: 2704-2713.

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