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Molecules 2012, 17(3), 2675-2682; doi:10.3390/molecules17032675
Article

Bioactive Phenolic Amides from Celtis africana

1, 1,* , 1, 1,2, 3, 4, 4 and 4
1 Department of Pharmacogonosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia 2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt 3 International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan 4 Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
* Author to whom correspondence should be addressed.
Received: 4 January 2012 / Revised: 20 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012
(This article belongs to the Section Natural Products)
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Abstract

Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were screened for their antioxidant, anti-inflammatory and acetylcholinestrease enzyme inhibitory activities. Compounds 13 showed significant antioxidant and anti-inflammatory activities and weak to moderate acetylcholinestrease enzyme inhibition activity.
Keywords: Celtis africana; antioxidant; anti-inflammatory; acetylcholinestrease enzyme inhibition Celtis africana; antioxidant; anti-inflammatory; acetylcholinestrease enzyme inhibition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Al-Taweel, A.M.; Perveen, S.; El-Shafae, A.M.; Fawzy, G.A.; Malik, A.; Afza, N.; Iqbal, L.; Latif, M. Bioactive Phenolic Amides from Celtis africana. Molecules 2012, 17, 2675-2682.

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