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Molecules 2012, 17(3), 2675-2682; doi:10.3390/molecules17032675

Bioactive Phenolic Amides from Celtis africana

1, 1,* , 1, 1,2, 3, 4, 4 and 4
1 Department of Pharmacogonosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia 2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt 3 International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan 4 Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
* Author to whom correspondence should be addressed.
Received: 4 January 2012 / Revised: 20 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012
(This article belongs to the Section Metabolites)
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Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were screened for their antioxidant, anti-inflammatory and acetylcholinestrease enzyme inhibitory activities. Compounds 13 showed significant antioxidant and anti-inflammatory activities and weak to moderate acetylcholinestrease enzyme inhibition activity.
Keywords: Celtis africana; antioxidant; anti-inflammatory; acetylcholinestrease enzyme inhibition Celtis africana; antioxidant; anti-inflammatory; acetylcholinestrease enzyme inhibition
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Al-Taweel, A.M.; Perveen, S.; El-Shafae, A.M.; Fawzy, G.A.; Malik, A.; Afza, N.; Iqbal, L.; Latif, M. Bioactive Phenolic Amides from Celtis africana. Molecules 2012, 17, 2675-2682.

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