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Molecules 2012, 17(3), 2675-2682; doi:10.3390/molecules17032675

Bioactive Phenolic Amides from Celtis africana

Department of Pharmacogonosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
Author to whom correspondence should be addressed.
Received: 4 January 2012 / Revised: 20 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012
(This article belongs to the Section Natural Products)
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Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were screened for their antioxidant, anti-inflammatory and acetylcholinestrease enzyme inhibitory activities. Compounds 13 showed significant antioxidant and anti-inflammatory activities and weak to moderate acetylcholinestrease enzyme inhibition activity.
Keywords: Celtis africana; antioxidant; anti-inflammatory; acetylcholinestrease enzyme inhibition Celtis africana; antioxidant; anti-inflammatory; acetylcholinestrease enzyme inhibition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Al-Taweel, A.M.; Perveen, S.; El-Shafae, A.M.; Fawzy, G.A.; Malik, A.; Afza, N.; Iqbal, L.; Latif, M. Bioactive Phenolic Amides from Celtis africana. Molecules 2012, 17, 2675-2682.

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