Molecules 2012, 17(3), 2643-2662; doi:10.3390/molecules17032643
Article

A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines

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Received: 6 February 2012; in revised form: 26 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1–3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation.
Keywords: microwave; 1,4-dihydropyridines; catalysis; green synthesis; bismuth nitrate
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MDPI and ACS Style

Bandyopadhyay, D.; Maldonado, S.; Banik, B.K. A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines. Molecules 2012, 17, 2643-2662.

AMA Style

Bandyopadhyay D, Maldonado S, Banik BK. A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines. Molecules. 2012; 17(3):2643-2662.

Chicago/Turabian Style

Bandyopadhyay, Debasish; Maldonado, Stephanie; Banik, Bimal K. 2012. "A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines." Molecules 17, no. 3: 2643-2662.

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