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Molecules 2012, 17(3), 2643-2662; doi:10.3390/molecules17032643

A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines

Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78539, USA
Undergraduate research participant.
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Author to whom correspondence should be addressed.
Received: 6 February 2012 / Revised: 26 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012
(This article belongs to the Section Organic Synthesis)
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Abstract

The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1–3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation.
Keywords: microwave; 1,4-dihydropyridines; catalysis; green synthesis; bismuth nitrate microwave; 1,4-dihydropyridines; catalysis; green synthesis; bismuth nitrate
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Bandyopadhyay, D.; Maldonado, S.; Banik, B.K. A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines. Molecules 2012, 17, 2643-2662.

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