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Benzoxetes and Benzothietes ¾ Heterocyclic Analogues of Benzocyclobutene
Molecules 2012, 17(2), 1890-1899; doi:10.3390/molecules17021890

A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides

1,* , 2, 1 and 1
1 Laboratoire de Chimie Organique Appliquée, Groupe de chimie Hétérocyclique, Département de Chimie, Faculté des Sciences, Université d’Annaba, BP 12, 23000, Algérie 2 Laboratoire de Chimie des Matériaux Organiques, Université de Tébessa, Route de Constantine, Tébessa, 12000, Algérie
* Author to whom correspondence should be addressed.
Received: 19 January 2012 / Revised: 6 February 2012 / Accepted: 8 February 2012 / Published: 14 February 2012
(This article belongs to the Special Issue Heterocycles)
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This work reports the synthesis of novel 1,4,3,5-oxathiadiazepanes 4,4-dioxides from the reaction of N’-benzyl-N-(2-hydroxyethyl)-sarcosine or proline sulfamide with aromatic aldehydes under acid catalysis. To prepare the starting materials N-Boc-sulfamide derivatives of sarcosine or proline were alkylated with benzyl alcohol under Mitsunobu reaction conditions, the Boc group was removed chemoselectively by acidolysis, and the resulting product reduced to the corresponding alcohol in good yields.
Keywords: cyclic sulfamides; benzodithiazine dioxides; benzoxathiazepine dioxides cyclic sulfamides; benzodithiazine dioxides; benzoxathiazepine dioxides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bendjeddou, A.; Abbaz, T.; Regainia, Z.; Aouf, N.-E. A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides. Molecules 2012, 17, 1890-1899.

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