Molecules 2012, 17(2), 1890-1899; doi:10.3390/molecules17021890

A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides

1,* email, 2, 1 and 1
Received: 19 January 2012; in revised form: 6 February 2012 / Accepted: 8 February 2012 / Published: 14 February 2012
(This article belongs to the Special Issue Heterocycles)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This work reports the synthesis of novel 1,4,3,5-oxathiadiazepanes 4,4-dioxides from the reaction of N’-benzyl-N-(2-hydroxyethyl)-sarcosine or proline sulfamide with aromatic aldehydes under acid catalysis. To prepare the starting materials N-Boc-sulfamide derivatives of sarcosine or proline were alkylated with benzyl alcohol under Mitsunobu reaction conditions, the Boc group was removed chemoselectively by acidolysis, and the resulting product reduced to the corresponding alcohol in good yields.
Keywords: cyclic sulfamides; benzodithiazine dioxides; benzoxathiazepine dioxides
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MDPI and ACS Style

Bendjeddou, A.; Abbaz, T.; Regainia, Z.; Aouf, N.-E. A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides. Molecules 2012, 17, 1890-1899.

AMA Style

Bendjeddou A, Abbaz T, Regainia Z, Aouf N-E. A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides. Molecules. 2012; 17(2):1890-1899.

Chicago/Turabian Style

Bendjeddou, Amel; Abbaz, Tahar; Regainia, Zine; Aouf, Nour-Eddine. 2012. "A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides." Molecules 17, no. 2: 1890-1899.

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