Next Article in Journal
Fructose Might Contribute to the Hypoglycemic Effect of Honey
Next Article in Special Issue
Synthesis and Antimicrobial Evaluation of Some Pyrazole Derivatives
Previous Article in Journal
A New Triterpene From Uncaria macrophylla and Its Antitumor Activity
Previous Article in Special Issue
Benzoxetes and Benzothietes ¾ Heterocyclic Analogues of Benzocyclobutene
Molecules 2012, 17(2), 1890-1899; doi:10.3390/molecules17021890
Article

A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides

1,* , 2, 1 and 1
Received: 19 January 2012; in revised form: 6 February 2012 / Accepted: 8 February 2012 / Published: 14 February 2012
(This article belongs to the Special Issue Heterocycles)
Download PDF [192 KB, uploaded 18 June 2014]
Abstract: This work reports the synthesis of novel 1,4,3,5-oxathiadiazepanes 4,4-dioxides from the reaction of N’-benzyl-N-(2-hydroxyethyl)-sarcosine or proline sulfamide with aromatic aldehydes under acid catalysis. To prepare the starting materials N-Boc-sulfamide derivatives of sarcosine or proline were alkylated with benzyl alcohol under Mitsunobu reaction conditions, the Boc group was removed chemoselectively by acidolysis, and the resulting product reduced to the corresponding alcohol in good yields.
Keywords: cyclic sulfamides; benzodithiazine dioxides; benzoxathiazepine dioxides cyclic sulfamides; benzodithiazine dioxides; benzoxathiazepine dioxides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Bendjeddou, A.; Abbaz, T.; Regainia, Z.; Aouf, N.-E. A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides. Molecules 2012, 17, 1890-1899.

AMA Style

Bendjeddou A, Abbaz T, Regainia Z, Aouf N-E. A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides. Molecules. 2012; 17(2):1890-1899.

Chicago/Turabian Style

Bendjeddou, Amel; Abbaz, Tahar; Regainia, Zine; Aouf, Nour-Eddine. 2012. "A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides." Molecules 17, no. 2: 1890-1899.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert