Molecules 2012, 17(2), 1883-1889; doi:10.3390/molecules17021883
Article

A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

Received: 10 January 2012; in revised form: 3 February 2012 / Accepted: 7 February 2012 / Published: 14 February 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (1H-1H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC50 values of 78.2 µg/mL and 73.9 µg/mL.
Keywords: Uncaria macrophylla; Rubiaceae; 3β, 6β, 19α-trihydroxy-12-oleanen-28-oic acid; antitumor activity
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MDPI and ACS Style

Sun, G.; Zhang, X.; Xu, X.; Yang, J.; Zhong, M.; Yuan, J. A New Triterpene From Uncaria macrophylla and Its Antitumor Activity. Molecules 2012, 17, 1883-1889.

AMA Style

Sun G, Zhang X, Xu X, Yang J, Zhong M, Yuan J. A New Triterpene From Uncaria macrophylla and Its Antitumor Activity. Molecules. 2012; 17(2):1883-1889.

Chicago/Turabian Style

Sun, Guangli; Zhang, Xiaopo; Xu, Xudong; Yang, Junshan; Zhong, Mingliang; Yuan, Jingquan. 2012. "A New Triterpene From Uncaria macrophylla and Its Antitumor Activity." Molecules 17, no. 2: 1883-1889.

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