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Molecules 2012, 17(2), 1883-1889; doi:10.3390/molecules17021883

A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
2
Department of Pharmacy, School of Pharmacy, Hebei United University, Tangshan, Hebei 063000, China
3
Guangxi Institute of Medicinal Plant Development, Nanning, Guangxi 530023, China
*
Author to whom correspondence should be addressed.
Received: 10 January 2012 / Revised: 3 February 2012 / Accepted: 7 February 2012 / Published: 14 February 2012
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Abstract

On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (1H-1H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC50 values of 78.2 µg/mL and 73.9 µg/mL.
Keywords: Uncaria macrophylla; Rubiaceae; 3β, 6β, 19α-trihydroxy-12-oleanen-28-oic acid; antitumor activity Uncaria macrophylla; Rubiaceae; 3β, 6β, 19α-trihydroxy-12-oleanen-28-oic acid; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Sun, G.; Zhang, X.; Xu, X.; Yang, J.; Zhong, M.; Yuan, J. A New Triterpene From Uncaria macrophylla and Its Antitumor Activity. Molecules 2012, 17, 1883-1889.

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