Abstract: On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (1H-1H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC50 values of 78.2 µg/mL and 73.9 µg/mL.
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Sun, G.; Zhang, X.; Xu, X.; Yang, J.; Zhong, M.; Yuan, J. A New Triterpene From Uncaria macrophylla and Its Antitumor Activity. Molecules 2012, 17, 1883-1889.
Sun G, Zhang X, Xu X, Yang J, Zhong M, Yuan J. A New Triterpene From Uncaria macrophylla and Its Antitumor Activity. Molecules. 2012; 17(2):1883-1889.
Sun, Guangli; Zhang, Xiaopo; Xu, Xudong; Yang, Junshan; Zhong, Mingliang; Yuan, Jingquan. 2012. "A New Triterpene From Uncaria macrophylla and Its Antitumor Activity." Molecules 17, no. 2: 1883-1889.