Molecules 2012, 17(12), 14288-14297; doi:10.3390/molecules171214288
Article

A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists

Xiaofeng Bao †,* email, Duliang Liu † email, Yanyan Jinemail and Yao Yangemail
Department of Biochemical Engineering, Nanjing University Science & Technology, Chemical Engineering Building B302, 200 Xiaolinwei, Nanjing 210094, China † These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 6 November 2012; in revised form: 27 November 2012 / Accepted: 28 November 2012 / Published: 3 December 2012
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Abstract: A facile synthesis for novel loperamide analogs as potential μ opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We also describe a mild and highly efficient protocol for the synthesis of compounds 6 and 7.
Keywords: loperamide analogs; μ opioid receptor agonist; morphine; opioid ligand receptors

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Cite This Article

MDPI and ACS Style

Bao, X.; Liu, D.; Jin, Y.; Yang, Y. A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists. Molecules 2012, 17, 14288-14297.

AMA Style

Bao X, Liu D, Jin Y, Yang Y. A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists. Molecules. 2012; 17(12):14288-14297.

Chicago/Turabian Style

Bao, Xiaofeng; Liu, Duliang; Jin, Yanyan; Yang, Yao. 2012. "A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists." Molecules 17, no. 12: 14288-14297.

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