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Molecules 2012, 17(12), 14288-14297; doi:10.3390/molecules171214288
Article

A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists

†,* ,
,
 and
Department of Biochemical Engineering, Nanjing University Science & Technology, Chemical Engineering Building B302, 200 Xiaolinwei, Nanjing 210094, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 6 November 2012 / Revised: 27 November 2012 / Accepted: 28 November 2012 / Published: 3 December 2012
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Abstract

A facile synthesis for novel loperamide analogs as potential μ opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We also describe a mild and highly efficient protocol for the synthesis of compounds 6 and 7.
Keywords: loperamide analogs; μ opioid receptor agonist; morphine; opioid ligand receptors loperamide analogs; μ opioid receptor agonist; morphine; opioid ligand receptors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bao, X.; Liu, D.; Jin, Y.; Yang, Y. A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists. Molecules 2012, 17, 14288-14297.

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