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Molecules 2012, 17(12), 14046-14057; doi:10.3390/molecules171214046
Article

4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis

1
, 1,†
, 1,* , 2
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 and 3
Received: 24 September 2012; in revised form: 30 October 2012 / Accepted: 20 November 2012 / Published: 27 November 2012
(This article belongs to the Section Metabolites)
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Abstract: Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxy-ethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol and sitosterol-3-O-β-D-glucopyranoside. The structures of these compounds were determined by spectroscopic analyses and B3LYP/STO-3G** theoretical studies.
Keywords: Holostylis reniformis; Aristolochiaceae; sesquiterpene; 4,5-seco-guaiane; megastigmane Holostylis reniformis; Aristolochiaceae; sesquiterpene; 4,5-seco-guaiane; megastigmane
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MDPI and ACS Style

Pereira, M.D.P.; da Silva, T.; Lopes, L.M.X.; Krettli, A.U.; Madureira, L.S.; Zukerman-Schpector, J. 4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis. Molecules 2012, 17, 14046-14057.

AMA Style

Pereira MDP, da Silva T, Lopes LMX, Krettli AU, Madureira LS, Zukerman-Schpector J. 4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis. Molecules. 2012; 17(12):14046-14057.

Chicago/Turabian Style

Pereira, Marcos D.P.; da Silva, Tito; Lopes, Lucia M.X.; Krettli, Antoniana U.; Madureira, Lucas S.; Zukerman-Schpector, Julio. 2012. "4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis." Molecules 17, no. 12: 14046-14057.



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