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Molecules 2012, 17(12), 14046-14057; doi:10.3390/molecules171214046
Article

4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis

1
,
1,†
,
1,* , 2
,
3
 and
3
1 Institute of Chemistry, São Paulo State University, UNESP, C.P. 355, 14801-970, Araraquara, SP, Brazil 2 Laboratory of Malaria, Institute René Rachou/FIOCRUZ, Av. Augusto de Lima 1715, 30190-002, Belo Horizonte, MG, Brazil 3 Department of Chemistry, Federal University of São Carlos, C.P. 676, 13565-905, São Carlos, SP, Brazil Current address: Federal University of Maranhão, Rua Urbano Santos, s/n, 65900-410, Centro de Ciências Sociais, Saúde e Tecnologia, Campus de Imperatriz, MA, Brazil.
* Author to whom correspondence should be addressed.
Received: 24 September 2012 / Revised: 30 October 2012 / Accepted: 20 November 2012 / Published: 27 November 2012
(This article belongs to the Section Natural Products)
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Abstract

Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxy-ethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol and sitosterol-3-O-β-D-glucopyranoside. The structures of these compounds were determined by spectroscopic analyses and B3LYP/STO-3G** theoretical studies.
Keywords: Holostylis reniformis; Aristolochiaceae; sesquiterpene; 4,5-seco-guaiane; megastigmane Holostylis reniformis; Aristolochiaceae; sesquiterpene; 4,5-seco-guaiane; megastigmane
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pereira, M.D.P.; da Silva, T.; Lopes, L.M.X.; Krettli, A.U.; Madureira, L.S.; Zukerman-Schpector, J. 4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis. Molecules 2012, 17, 14046-14057.

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