Molecules 2012, 17(12), 14046-14057; doi:10.3390/molecules171214046
Article

4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis

1 Institute of Chemistry, São Paulo State University, UNESP, C.P. 355, 14801-970, Araraquara, SP, Brazil 2 Laboratory of Malaria, Institute René Rachou/FIOCRUZ, Av. Augusto de Lima 1715, 30190-002, Belo Horizonte, MG, Brazil 3 Department of Chemistry, Federal University of São Carlos, C.P. 676, 13565-905, São Carlos, SP, Brazil Current address: Federal University of Maranhão, Rua Urbano Santos, s/n, 65900-410, Centro de Ciências Sociais, Saúde e Tecnologia, Campus de Imperatriz, MA, Brazil.
* Author to whom correspondence should be addressed.
Received: 24 September 2012; in revised form: 30 October 2012 / Accepted: 20 November 2012 / Published: 27 November 2012
(This article belongs to the Section Natural Products)
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Abstract: Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxy-ethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol and sitosterol-3-O-β-D-glucopyranoside. The structures of these compounds were determined by spectroscopic analyses and B3LYP/STO-3G** theoretical studies.
Keywords: Holostylis reniformis; Aristolochiaceae; sesquiterpene; 4,5-seco-guaiane; megastigmane

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MDPI and ACS Style

Pereira, M.D.P.; da Silva, T.; Lopes, L.M.X.; Krettli, A.U.; Madureira, L.S.; Zukerman-Schpector, J. 4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis. Molecules 2012, 17, 14046-14057.

AMA Style

Pereira MDP, da Silva T, Lopes LMX, Krettli AU, Madureira LS, Zukerman-Schpector J. 4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis. Molecules. 2012; 17(12):14046-14057.

Chicago/Turabian Style

Pereira, Marcos D.P.; da Silva, Tito; Lopes, Lucia M.X.; Krettli, Antoniana U.; Madureira, Lucas S.; Zukerman-Schpector, Julio. 2012. "4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis." Molecules 17, no. 12: 14046-14057.

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