Molecules 2012, 17(12), 14046-14057; doi:10.3390/molecules171214046
Article

4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis

1email, 1,†email, 1,* email, 2email, 3email and 3
Received: 24 September 2012; in revised form: 30 October 2012 / Accepted: 20 November 2012 / Published: 27 November 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxy-ethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol and sitosterol-3-O-β-D-glucopyranoside. The structures of these compounds were determined by spectroscopic analyses and B3LYP/STO-3G** theoretical studies.
Keywords: Holostylis reniformis; Aristolochiaceae; sesquiterpene; 4,5-seco-guaiane; megastigmane
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MDPI and ACS Style

Pereira, M.D.P.; da Silva, T.; Lopes, L.M.X.; Krettli, A.U.; Madureira, L.S.; Zukerman-Schpector, J. 4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis. Molecules 2012, 17, 14046-14057.

AMA Style

Pereira MDP, da Silva T, Lopes LMX, Krettli AU, Madureira LS, Zukerman-Schpector J. 4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis. Molecules. 2012; 17(12):14046-14057.

Chicago/Turabian Style

Pereira, Marcos D.P.; da Silva, Tito; Lopes, Lucia M.X.; Krettli, Antoniana U.; Madureira, Lucas S.; Zukerman-Schpector, Julio. 2012. "4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis." Molecules 17, no. 12: 14046-14057.


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