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Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Division of Marine Biotechnology, Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan
Department of Life Science, National Taitung University, Taitung 950, Taiwan
Industrial Technology Research Institute, Clean Energy and Eco-Technology Center, Tainan 734, Taiwan
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Authors to whom correspondence should be addressed.
Received: 22 October 2012; in revised form: 18 November 2012 / Accepted: 23 November 2012 / Published: 27 November 2012
Abstract: Two norcembranoidal diterpenes, 5-episinuleptolide acetate (1) and scabrolide D (2), were isolated from a Formosan octocoral identified as Sinularia sp. The structures of norcembranoids 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of known analogues and 1 was proven to be a new natural product. Norcembranoid 1 was found to exhibit cytotoxicity toward a panel of tumor cells.
Keywords: Sinularia; norcembranoidal diterpene; cytotoxicity
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Yen, W.-H.; Hu, L.-C.; Su, J.-H.; Lu, M.-C.; Twan, W.-H.; Yang, S.-Y.; Kuo, Y.-C.; Weng, C.-F.; Lee, C.-H.; Kuo, Y.-H.; Sung, P.-J. Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.. Molecules 2012, 17, 14058-14066.
Yen W-H, Hu L-C, Su J-H, Lu M-C, Twan W-H, Yang S-Y, Kuo Y-C, Weng C-F, Lee C-H, Kuo Y-H, Sung P-J. Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.. Molecules. 2012; 17(12):14058-14066.
Yen, Wei-Hsuan; Hu, Li-Chung; Su, Jui-Hsin; Lu, Mei-Chin; Twan, Wen-Hung; Yang, Show-Ying; Kuo, Yung-Chi; Weng, Ching-Feng; Lee, Chia-Hung; Kuo, Yueh-Hsiung; Sung, Ping-Jyun. 2012. "Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.." Molecules 17, no. 12: 14058-14066.