Molecules 2012, 17(12), 14058-14066; doi:10.3390/molecules171214058
Article

Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.

Wei-Hsuan Yen 1,2 email, Li-Chung Hu 1,2 email, Jui-Hsin Su 1,2,3 email, Mei-Chin Lu 1,2 email, Wen-Hung Twan 4 email, Show-Ying Yang 5 email, Yung-Chi Kuo 5 email, Ching-Feng Weng 1 email, Chia-Hung Lee 1 email, Yueh-Hsiung Kuo 6,* email and Ping-Jyun Sung 1,2,3,7,* email
1 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Division of Marine Biotechnology, Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan 4 Department of Life Science, National Taitung University, Taitung 950, Taiwan 5 Industrial Technology Research Institute, Clean Energy and Eco-Technology Center, Tainan 734, Taiwan 6 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan 7 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Authors to whom correspondence should be addressed.
Received: 22 October 2012; in revised form: 18 November 2012 / Accepted: 23 November 2012 / Published: 27 November 2012
(This article belongs to the Section Natural Products)
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Abstract: Two norcembranoidal diterpenes, 5-episinuleptolide acetate (1) and scabrolide D (2), were isolated from a Formosan octocoral identified as Sinularia sp. The structures of norcembranoids 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of known analogues and 1 was proven to be a new natural product. Norcembranoid 1 was found to exhibit cytotoxicity toward a panel of tumor cells.
Keywords: Sinularia; norcembranoidal diterpene; cytotoxicity

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Cite This Article

MDPI and ACS Style

Yen, W.-H.; Hu, L.-C.; Su, J.-H.; Lu, M.-C.; Twan, W.-H.; Yang, S.-Y.; Kuo, Y.-C.; Weng, C.-F.; Lee, C.-H.; Kuo, Y.-H.; Sung, P.-J. Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.. Molecules 2012, 17, 14058-14066.

AMA Style

Yen W-H, Hu L-C, Su J-H, Lu M-C, Twan W-H, Yang S-Y, Kuo Y-C, Weng C-F, Lee C-H, Kuo Y-H, Sung P-J. Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.. Molecules. 2012; 17(12):14058-14066.

Chicago/Turabian Style

Yen, Wei-Hsuan; Hu, Li-Chung; Su, Jui-Hsin; Lu, Mei-Chin; Twan, Wen-Hung; Yang, Show-Ying; Kuo, Yung-Chi; Weng, Ching-Feng; Lee, Chia-Hung; Kuo, Yueh-Hsiung; Sung, Ping-Jyun. 2012. "Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.." Molecules 17, no. 12: 14058-14066.

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