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Molecules 2012, 17(12), 14058-14066; doi:10.3390/molecules171214058
Article

Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.

1,2
,
1,2
,
1,2,3
,
1,2
,
4
,
5
,
5
,
1
,
1
,
6,*  and 1,2,3,7,*
1 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Division of Marine Biotechnology, Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan 4 Department of Life Science, National Taitung University, Taitung 950, Taiwan 5 Industrial Technology Research Institute, Clean Energy and Eco-Technology Center, Tainan 734, Taiwan 6 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan 7 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Authors to whom correspondence should be addressed.
Received: 22 October 2012 / Revised: 18 November 2012 / Accepted: 23 November 2012 / Published: 27 November 2012
(This article belongs to the Section Natural Products)
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Abstract

Two norcembranoidal diterpenes, 5-episinuleptolide acetate (1) and scabrolide D (2), were isolated from a Formosan octocoral identified as Sinularia sp. The structures of norcembranoids 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of known analogues and 1 was proven to be a new natural product. Norcembranoid 1 was found to exhibit cytotoxicity toward a panel of tumor cells.
Keywords: Sinularia; norcembranoidal diterpene; cytotoxicity Sinularia; norcembranoidal diterpene; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yen, W.-H.; Hu, L.-C.; Su, J.-H.; Lu, M.-C.; Twan, W.-H.; Yang, S.-Y.; Kuo, Y.-C.; Weng, C.-F.; Lee, C.-H.; Kuo, Y.-H.; Sung, P.-J. Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.. Molecules 2012, 17, 14058-14066.

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