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Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia
Dental Research & Training Unit and Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia
Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (LIMBR), School of Medicine (SoM), Faculty of Health, Institute for Frontier Materials (IFM), Deakin University, Waurn Ponds, Victoria 3217, Australia
* Author to whom correspondence should be addressed.
Received: 9 November 2012; in revised form: 15 November 2012 / Accepted: 19 November 2012 / Published: 23 November 2012
Abstract: The aim of the present study was to evaluate the hepatoprotective activity of lantadene A against acetaminophen-induced liver toxicity in mice was studied. Activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin, along with histo-pathological analysis. Silymarin was used as positive control. A bimodal pattern of behavioural toxicity was exhibited by the lantadene A-treated group at the beginning of the treatment. However, treatment with lantadene A and silymarin resulted in an increase in the liver weight compared with the acetaminophen treated group. The results of the acetaminophen-induced liver toxicity experiments showed that mice treated with lantadene A (500 mg/kg) showed a significant decrease in the activity of ALT, AST and ALP and the level of bilirubin, which were all elevated in the acetaminophen treated group (p < 0.05). Histological studies supported the biochemical findings and a maximum improvement in the histoarchitecture was seen. The lantadene A-treated group showed remarkable protective effects against histopathological alterations, with comparable results to the silymarin treated group. The current study confirmed the hepatoprotective effects of lantadene A against the model hepatotoxicant acetaminophen, which is likely related to its potent antioxidative activity.
Keywords: acetaminophen; hepatoprotective; antioxidant activity; lantadene A; triterpenes
This paper was retracted on 27 March 2013: http://www.mdpi.com/1420-3049/18/4/3839
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The authors would like to withdraw their paper because they are unable to characterize the original sample, now used up, and they have been unable to obtain a verified equivalent one from the local commercial supplier, so they can no longer associate with any confidence their experimental results with the compound lantadene A
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MDPI and ACS Style
Grace-Lynn, C.; Chen, Y.; Latha, L.Y.; Kanwar, J.R.; Jothy, S.L.; Vijayarathna, S.; Sasidharan, S. Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage. Molecules 2012, 17, 13937-13947.
Grace-Lynn C, Chen Y, Latha LY, Kanwar JR, Jothy SL, Vijayarathna S, Sasidharan S. Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage. Molecules. 2012; 17(12):13937-13947.
Grace-Lynn, Chong; Chen, Yeng; Latha, Lachimanan Y.; Kanwar, Jagat R.; Jothy, Subramanion L.; Vijayarathna, Soundararajan; Sasidharan, Sreenivasan. 2012. "Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage." Molecules 17, no. 12: 13937-13947.