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A Comparative Uptake Study of Multiplexed PET Tracers in Mice with Turpentine-Induced Inflammation
Department of Nuclear Medicine, The First Afﬁliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 10 September 2012; in revised form: 17 November 2012 / Accepted: 20 November 2012 / Published: 26 November 2012
Abstract: The potential value of multiplexed positron emission tomography (PET) tracers in mice with turpentine-induced inflammation was evaluated and compared with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) for glucose metabolism imaging. These PET tracers included [18F]fluoromethylcholine ([18F]FCH) for choline metabolism imaging, (S-[11C]methyl)-D-cysteine ([11C]DMCYS) for amino acid metabolism imaging, [11C]bis(zinc(II)-dipicolylamine) ([11C]DPA-Zn2+) for apoptosis imaging, 2-(4-N-[11C]-methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB) for β amyloid binding imaging, and [18F]fluoride (18F−) for bone metabolism imaging. In mice with turpentine-induced inflammation mice, the biodistribution of all the tracers mentioned above at 5, 15, 30, 45, and 60 min postinjection was determined. Also, the time-course curves of the tracer uptake ratios for inflammatory thigh muscle (IM) to normal uninflammatory thigh muscle (NM), IM to blood (BL), IM to brain (BR), and IM to liver (LI) were acquired, respectively. Moreover, PET imaging with the tracers within 60 min postinjection on a clinical PET/CT scanner was also conducted. [18F]FDG and 18F− showed relatively higher uptake ratios for IM to NM, IM to BL, IM to BR, and IM to LI than [18F]FCH, [11C]DPA-Zn2+, [11C]DMCYS and [11C]PIB, which were highly consistent with the results delineated in PET images. The results demonstrate that 18F− seems to be a potential PET tracer for inflammation imaging. [18F]FCH and [11C]DMCYS, with lower accumulation in inflammatory tissue than [18F]FDG, are not good PET tracers for inflammation imaging. As a promising inflammatory tracer, the chemical structure of [11C]DPA-Zn2+ needs to be further optimized.
Keywords: inﬂammation; PET imaging; turpentine oil; [18F]FDG; multiple PET tracers
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Huang, T.; Wang, H.; Tang, G.; Liang, X.; Nie, D.; Yi, C.; Wu, K. A Comparative Uptake Study of Multiplexed PET Tracers in Mice with Turpentine-Induced Inflammation. Molecules 2012, 17, 13948-13959.
Huang T, Wang H, Tang G, Liang X, Nie D, Yi C, Wu K. A Comparative Uptake Study of Multiplexed PET Tracers in Mice with Turpentine-Induced Inflammation. Molecules. 2012; 17(12):13948-13959.
Huang, Tingting; Wang, Hongliang; Tang, Ganghua; Liang, Xiang; Nie, Dahong; Yi, Chang; Wu, Kening. 2012. "A Comparative Uptake Study of Multiplexed PET Tracers in Mice with Turpentine-Induced Inflammation." Molecules 17, no. 12: 13948-13959.