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Communication

Palladium-Catalyzed Multicomponent Synthesis of 2-Imidazolines from Imines and Acid Chlorides

Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 2K6, Canada
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(12), 13759-13768; https://doi.org/10.3390/molecules171213759
Submission received: 25 October 2012 / Revised: 13 November 2012 / Accepted: 14 November 2012 / Published: 22 November 2012
(This article belongs to the Special Issue Transition Metals Catalysis)

Abstract

:
We describe the palladium-catalyzed multicomponent synthesis of 2-imidazolines. This reaction proceeds via the coupling of imines, acid chlorides and carbon monoxide to form imidazolinium carboxylates, followed by a decarboxylation. Decarboxylation in CHCl3 is found to result in a mixture of imidazolinium and imidazolium salts. However, the addition of benzoic acid suppresses aromatization, and generates the trans-disubstituted imidazolines in good yield. Combining this reaction with subsequent nitrogen deprotection provides an overall synthesis of imidazolines from multiple available building blocks.

1. Introduction

2-Imidazolines, the 4,5-reduced counterpart of imidazoles, are an important class of small molecules. The skeletal core of imidazolines can be found in many biological active compounds, including anti-cancer agents [1,2], antidepressants [3,4], analgesics [5,6], and anti-inflammatory agents [7,8]. In addition, imidazolines are useful in coordination chemistry, serving as N-donor ligands in various transition metals complexes [9,10,11] or as precursors to N-heterocyclic carbenes [12,13].
The traditional method to synthesize imidazolines involves the coupling of a 1,2-diamine with an appropriate condensation partner, such as aldehydes, esters, amides or imidates [14,15,16,17,18]. More recently, other synthetic routes to imidazolines have been reported, including the ring opening of aziridines [19,20], the reaction of imines with isocyanates [21,22,23], and the cycloaddition of imines to azomethine ylides [24]. While these methods are each effective, they often require the use of synthetic precursors which can themselves require a multistep synthesis. This can make it challenging to both generate polysubstituted imidazolines, and to diversify their structure to modify properties.
We have previously reported a palladium-catalyzed multicomponent synthesis of imidazolinium carboxylates from imines, acid chlorides and CO (Scheme 1) [25,26,27]. Transition-metal catalyzed multicomponent reactions have emerged as a powerful tool in synthesis as they can allow the controlled assembly of multiple simple units directly into complex products [28,29,30,31,32,33]. The generation of 1 proceeds via imine cycloaddition to an in situ generated münchnone (Scheme 1). This reactivity is similar to alkene cycloaddition to münchnones, which, upon themolysis, can undergo decarboxylation to yield pyrrolines [34,35]. As such, we became interested in the analogous reaction of 1. The latter could provide a modular assembly of imidazolines. Tepe and co-workers have recently reported that similar 2-imidazoline carboxylates can undergo thermal decarboxylation under certain conditions [36]. This observation prompted us to investigate decarboxylation as a platform to access substituted imidazolines from 1.

2. Results and Discussion

In order to test the viability of this chemistry in imidazoline synthesis, imidazolinium carboxylate 1a (R1, R4 = benzyl, R2, R3, R5 = phenyl) was prepared via the palladium catalyzed multicomponent synthesis shown in Scheme 1 [JOHNPHOS = P(t-Bu)2(2-biphenyl)]. The heating of 1a in CDCl3 at 65 °C for 6 h leads to the complete conversion of starting compound and the formation of three products, identified as the trans- and cis-isomers of the imidazolinium 2a, as well as the aromatized imidazolium 3a in yields of 59:16:13, respectively (Scheme 2) [37]. The thermal decarboxylation of 1a presumably proceeds via the initial loss of CO2 to generate the ylide 1a', which could either be protonated by the solvent (compound 2a) or undergo oxidation to form 3a. To favor the generation of 2a, we examined the influence of acids on the reaction. As shown in Table 1, performing the decarboxylation with one equivalent of benzoic acid leads to the exclusive formation of the imidazoline in 78% yield (entry 1). Other organic carboxylic acids are also effective, and result in similar yields and selectivities (entries 2–3).
In all cases, no significant amount of aromatized product 3a is observed, indicating a rapid protonation of the ylide intermediate. The use of stronger acids did not lead to decarboxylation (entries 4–6). In addition, the use of a large excess of benzoic acid inhibited the reaction (entry 7). This suggests that the decarboxylation occurs from zwitterionic 1a.
The above reactions all generate imidazolium salt 2a as a mixture of stereoisomers. However, during our studies on this decarboxylation, we were surprised to find that the use of wet chloroform solvent significantly favored the generation of trans-2a over the cis-isomer. This can be performed in a more controlled fashion, where the addition of an excess of water (20 equiv.) with benzoic acid leads to the formation of trans-2a in 86% yield, and almost completely suppresses the cis-product (entry 8). The mechanism by which water influences the protonation is not known, although a control experiment using water without acid leads to decomposition of the starting material (entry 9), suggesting water in concert with benzoic acid results in a proton source that favors proton transfer on the same face as the pendant aromatic unit.
This sequence of palladium catalyzed multicomponent coupling and decarboxylation provides a method to selectively generate trans-substituted imidazolinium salts. As imines are readily available from aldehydes and amines, it is straightforward to synthesize asymmetrically substituted imidazolines. This can include the incorporation of orthogonal nitrogen protecting groups. For example, imidazolinium carboxylate 1b bearing both N-allyl and N-para-methoxybenzyl (PMB) protecting groups can be generated through palladium catalysis (Scheme 3). Subsequent decarboxylation followed by deallylation yields imidazoline 4b. Alternatively, the para-methoxybenzyl group can be cleaved from imidazolinium cation 2b, affording imidazoline 5b.
As an illustration of the versatility of this approach, a number of orthogonally substituted imidazolines have been generated via the palladium catalyzed synthesis of 1 and selective decarboxylation (Scheme 4). The substituents of the imidazoline core can be varied by choosing the appropriate imine(s) and acid chloride, while functional groups such as esters, aryl ethers, alkenes and aryl-halides are all tolerated. This modularity can allow for the rapid synthesis of imidazolines with independent control of four separate substituents.

3. Experimental

3.1. General Considerations

All solvents used were dried by passage through a column of alumina prior to use. All common reagents were purchased from Aldrich (Oakville, Canada) and used as received unless otherwise noted. Pd(PPh3)4 was purchased from Strem (Boston, MA, USA) and stored in a nitrogen glovebox. Imines were synthesized by the condensation of the appropriate aldehyde and amine in the presence of MgSO4 and purified by distillation under vaccum, according literature methods [38]. Amide-chelated palladium catalysts were synthesized according to a literature protocol [39]. N,N-diisopropylethylamine was distilled over CaH2 prior to use. Carbon monoxide was purchased at 99.99% purity MEGS (Montreal, Canada) and used as received. NMR characterization was performed at 300 MHz, 400 MHz and 500 MHz for 1H-NMR and 75 MHz and 126 MHz for 13C-NMR on Varian spectrometers. Resonances at 145.5 and 53.2 ppm in the 13C-NMR spectra are artifacts generated during data collection and do not represent real product signals. Chemical shifts are reported in parts per million relative to the residual solvent signal. Mass spectra were recorded on a Agilent LC-MSD TOF high-resolution electrospray ionization quadrupole spectrometer.

3.2. Synthesis of trans-1,3-Dibenzyl-2,4,5-triphenyl-4,5-dihydro-3H-imidazol-1-ium (trans-2a) and cis-1,3-Dibenzyl-2,4,5-triphenyl-4,5-dihydro-3H-imidazol-1-ium (cis-2a)

Imidazolinium carboxylate 1a (52.2 mg, 0.100 mmol) and benzoic acid (12.2 mg, 0.100 mmol) were dissolved in CHCl3 (5 mL). Benzyl benzoate (10 μL) was added as an internal standard and an aliquot of this mixture was taken for 1H-NMR analysis. Water (36 μL, 2 mmol) was added by micropipette and the vial was capped and heated at 65 °C for 6 h. The solvent was then removed and the yield of the products was determined by 1H-NMR analysis in CDCl3. The identity of cis- and trans-2a was determined by the palladium-catalyzed cleavage of the benzyl protecting groups (5 mol% Pd(OH)2, AcOH, 65 °C, 48 h), and comparing the resulting imidazoline to previously reported compounds [16,40].

3.3. Synthesis of 1,3-Dibenzyl-2,4,5-triphenyl-3H-imidazol-1-ium (3a)

In a septum sealed NMR tube, 1-benzyl-2,4,5-triphenyl-1H-imidazole [41] (19.5 mg, 0.05 mmol) was dissolved in CDCl3 (1.5 mL). Benzyl bromide (9.0 μL, 0.075 mmol) was added by microsyringe. The tube was heated at 75 °C for 3 days. The solvent was removed in vacuo and the resulting residue was redissolved in CH2Cl2 (500 μL). Diethyl ether (10 mL) was slowly layered on top of this solution, resulting in the precipitation of a white solid. This solid was further triturated with diethyl ether to afford 3a as a white solid. (12.2 mg, 43%) 1H-NMR (500 MHz, CDCl3): δ 8.00–7.99 (m, 1H), 7.56–7.53 (m, 3H), 7.46 (t, J = 7.7 Hz, 1H), 7.32–7.29 (m, 1H), 7.27–7.23 (m, 2H), 7.20–7.14 (m, 3H), 6.76–6.75 (m, 2H), 5.25 (s, 2H). 13C-NMR (126 MHz, CDCl3): δ 145.1, 134.1, 132.8, 132.3, 131.5, 131.4, 130.0, 129.4, 128.8, 128.7, 128.2, 127.1, 125.4, 122.1, 50.7 HRMS (ESI): C35H29N2 (M)+ calcd; 477.23359 observed; 477.23253

3.4. Synthesis of 1-(4-Methoxy-benzyl)-2,4,5-triphenyl-4,5-dihydro-1H-imidazole (4b)

Compound 1b was prepared according to a literature procedure [25]. In a glovebox under nitrogen atmosphere, (4-CH3C6H4)HC=NCH2(4-C6H4OCH3) (67.8 mg, 0.300 mmol) and benzoyl chloride (54.8 mg, 0.390 mmol) were dissolved in CH3CN (5 mL). The mixture was then transferred to a 50 mL thick walled Schlenk tube and allowed to stir for 15 min. [Pd(Cl)[η2-CH(4-CH3C6H4)-NCH2(4-C6H4OMe)COPh]]2 (14.2 mg, 0.015 mmol), P(t-Bu)2(2-biphenyl) (13.4 mg, 0.045 mmol) and N,N-diisopropylethylamine (50.3 mg, 0.390 mmol) were combined in THF (5 mL) and added to the mixture. The solution was stirred for 5 min before the Schlenk tube was briefly evacuated, brought outside of the glovebox, charged with 4 atm of CO, and heated at 45 °C for 16 h. The CO atmosphere was replaced with nitrogen, the tube was brought into the glovebox, and PhHC=N(CH2CH=CH2) (87.0 mg, 0.600 mmol) and PhSO3H (40.0 mg, 0.25 mmol) in THF (2 mL) were added. The mixture was stirred for 16 h. The reaction mixture was diluted with CH2Cl2 (25 mL), then sequentially washed with brine, 0.1 M HCl and sat. NaHCO3, extracting with additional CH2Cl2 in each wash. The combined organic layers were dried with Na2SO4, filtered and concentrated to 1 mL of solvent. Diethyl ether (20 mL) was slowly layered on the solution resulting in precipitation of the product, which was subsequently triturated with additional diethyl ether, providing 1b as a yellow solid which was immediately used the subsequent decarboxylation reaction.
To a sample of 1b (50.2 mg, 0.100 mmol), was added benzoic acid (12.2 mg, 0.100 mmol) in CHCl3 (5 mL). Water (36 μL, 2 mmol) was added by micropipette and the vial was capped and heated at 65 °C for 6 h. The mixture was allowed to cool to room temperature, diluted with CH2Cl2 (20 mL), then washed with brine, extracting with additional CH2Cl2. The combined organic layers were dried with Na2SO4, filtered and concentrated to give imidazolinium 2b as a yellow solid. This compound was transferred without further purification to a dry Schlenk flask and placed under N2. Pd(PPh3)4 (11.5 mg, 0.010 mmol) was added as a solution in dry CH2Cl2 (2 mL) followed by PhSiH3 (25.0 μL, 0.2 mmol) in CH2Cl2 (2 mL). The reaction mixture was allowed to stir at room temperature for 16 h. The solution was then diluted with additional with CH2Cl2 (20 mL) and washed with brine, extracting with additional CH2Cl2. The organic layers were dried with Na2SO4, filtered and concentrated to give a brown solid which was purified by flash column chromatography (5% MeOH in CH2Cl2) to yield imidazoline 4b as a brown solid (31.9 mg, 76% dr: 13:1) 1H-NMR (300 MHz, CDCl3): δ 7.84 (dt, J = 6.7, 3.3 Hz, 2H), 7.57–7.51 (m, 4H), 7.43–7.20 (m, 10H), 7.12–7.07 (m, 2H), 6.92–6.83 (m, 2H), 6.75 (d, J = 8.6 Hz, 2H), 5.03–5.00 (m, 1H), 4.70 (d, J = 15.3 Hz, 1H), 4.38–4.35 (m, 1H), 3.87 (d, J = 15.3 Hz, 1H), 3.76 (d, J = 7.0 Hz, 3H). 13C-NMR (75 MHz; CDCl3): δ 166.0, 159.0, 143.3, 141.3, 130.5, 129.3, 128.9, 128.83, 128.77, 128.69, 128.5, 127.97, 127.90, 127.88, 127.2, 126.7, 113.9, 77.2, 72.3, 55.3, 49.0 HRMS (ESI): C29H26N2O (M+H)+ calcd; 419.21179 observed; 419.21203.
1-Benzyl-2,4,5-triphenyl-4,5-dihydro-1H-imidazole (4c). Yield: 39% dr: 9:1); 1H-NMR (400 MHz, CDCl3): δ 7.86–7.81 (m, 2H), 7.51–7.48 (m, 3H), 7.41–7.19 (m, 12H), 7.13–7.11 (m, 2H), 6.97–6.94 (m, 2H), 5.00 (d, J = 8.6 Hz, 1H), 4.73 (d, J = 15.6 Hz, 1H), 4.35 (d, J = 8.6 Hz, 1H), 3.93 (d, J = 15.6 Hz, 1H). 13C-NMR (75 MHz, CDCl3): δ 166.0, 143.8, 141.8, 136.4, 131.2, 130.2, 128.9, 128.72, 128.68, 128.5, 128.4, 128.0, 127.8, 127.5, 127.2, 127.0, 126.8, 77.2, 72.5, 49.6 HRMS (ESI): C28H24N2 (M+H)+ calcd; 389.20123 observed; 389.20148.
4-(1-Ethyl-2-phenyl-5-p-tolyl-4,5-dihydro-1H-imidazol-4-yl)-benzoic acid methyl ester (4d). Yield: 60% dr: 20:1; 1H-NMR (500 MHz, CDCl3) δ 8.04–8.03 (m, 2H), 7.91–7.89 (m, 1H), 7.79–7.76 (m, 2H), 7.53–7.47 (m, 3H), 7.42–7.38 (m, 3H), 7.32–7.22 (m, 5H), 5.15 (d, J = 8.9 Hz, 1H), 4.46 (d, J = 9.0 Hz, 1H), 3.35–3.28 (m, 1H), 3.11–3.03 (m, 1H), 2.39 (s, 3H), 0.90–0.84 (m, 4H). 13C-NMR (CDCl3, 126 MHz): δ 167.2, 167.0, 148.5, 138.2, 138.1, 130.6, 130.0, 129.8, 129.2, 128.6, 128.4, 127.8, 127.1, 126.6, 75.9, 73.9, 52.1, 41.1, 21.2, 13.1 HRMS (ESI): C26H26N2O2 (M+H)+ calcd; 399.20670 observed; 399.20664.
1-Benzyl-4-(4-bromo-phenyl)-2-(4-methoxy-phenyl)-5-p-tolyl-4,5-dihydro-1H-imidazole (4e). Yield 63% dr: 20:1; 1H-NMR (500 MHz, CDCl3): δ 7.77–7.74 (m, 2H), 7.37–7.34 (m, 2H), 7.24–7.16 (m, 7H), 7.02–6.99 (m, 2H), 6.96–6.92 (m, 4H), 4.91 (d, J = 8.6 Hz, 1H), 4.75 (d, J = 15.6 Hz, 1H), 4.21 (d, J = 8.7 Hz, 1H), 3.88 (d, J = 15.6 Hz, 1H), 3.87(s, 3H), 2.39 (s, 3H). 13C-NMR (75 MHz, CDCl3): δ 166.0, 161.3, 142.8, 138.1, 137.9, 136.2, 131.5, 130.3, 129.7, 128.6, 128.4, 128.0, 127.7, 127.1, 122.6, 121.0, 114.1, 76.3, 72.2, 55.4, 49.5, 21.2 HRMS (ESI): C30H27BrNO2 (M+H)+ calcd; 511.13795 observed; 511.13808.

3.5. Synthesis of 1-Allyl-2,4,5-triphenyl-4,5-dihydro-1H-imidazole (5b)

Compound 2b (95.6 mg, 0.19 mmol) was prepared as described above, and transferred without further purification to a dry Schlenk flask and placed under N2. The solid was dissolved in dry CH2Cl2 (5 mL) and cooled to 0 °C. BBr3 (1.0 M in CH2Cl2, 2 mL, 2 mmol, 10 equiv.) was added slowly and the mixture was allowed to warm to room temperature. The solution was stirred at room temperature for 2 h. Sodium hydroxide (10 mL 1.0M solution) was rapidly added to the solution, which was then diluted with CH2Cl2 (20 mL), and washed with brine, extracting with additional CH2Cl2. The organic layers were dried with Na2SO4, filtered, and concentrated to give a yellow oil which was purified by flash column chromatography (5% MeOH in CH2Cl2) to give a imidazoline 5b as a yellow oil (27.8 mg, 40%, dr: 20:1) 1H-NMR (400 MHz, CDCl3): δ 7.78–7.74 (m, 2H), 7.51–7.44 (m, 3H), 7.43–7.32 (m, 6H), 7.30–7.26 (m, 3H), 5.55 (m, 1H), 5.06–4.92 (m, 3H), 4.51 (d, J = 8.9 Hz, 1H), 3.96–3.91 (m, 1H), 3.47 (dd, J = 16.1, 7.3 Hz, 1H). 13C-NMR (126 MHz; CDCl3): δ 166.4, 144.0, 142.0, 133.0, 131.2, 130.1, 128.9, 128.52, 128.47, 128.45, 127.8, 127.2, 127.1, 126.8, 118.2, 77.8, 74.0, 49.1 HRMS (ESI): C24H22N2 (M+H)+ calcd; 339.18558 observed; 339.18605.

4. Conclusions

In conclusion, the coupling of the palladium catalyzed multicomponent synthesis of imidazolium carboxylates with stereoselective decarboxylation provides a new and modular synthesis of imidazolines. Efforts towards elucidating the mechanism of the decarboxylation reaction, and directing this towards other classes of heterocyclic products, are currently underway.

Supplementary Materials

Supplementary materials can be accessed at: https://www.mdpi.com/1420-3049/17/12/13759/s1.

References and Notes

  1. Vassilev, L.T.; Vu, B.T.; Graves, B.; Carvajal, D.; Podlaski, F.; Filipovic, Z.; Kong, N.; Kammlott, U.; Lukacs, C.; Klein, C.; et al. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2. Science 2004, 303, 844–848. [Google Scholar] [CrossRef] [PubMed]
  2. Sharma, V.; Lansdell, T.A.; Peddibhotla, S.; Tepe, J.J. Sensitization of Tumor Cells toward Chemotherapy: Enhancing the Efficacy of Camptothecin with Imidazolines. Chem. Biol. 2004, 11, 1689–1699. [Google Scholar] [CrossRef] [PubMed]
  3. Gentili, F.; Pizzinat, N.; Ordener, C.; Marchal-Victorion, S.; Maurel, A.; Hofmann, R.; Renard, P.; Delagrange, P.; Pigini, M.; Parini, A.; et al. 3-[5-(4,5-Dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a Promising Reversible and Selective Peripheral MAO-A Inhibitor. J. Med. Chem. 2006, 49, 5578–5586. [Google Scholar] [CrossRef] [PubMed]
  4. Hlasta, D.J.; Luttinger, D.; Perrone, M.H.; Silbernagel, M.J.; Ward, S.J.; Haubrich, D.R. α2-Adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines. J. Med. Chem. 1987, 30, 1555–1562. [Google Scholar] [CrossRef] [PubMed]
  5. Li, J.-X.; Zhang, Y. Imidazoline I2 receptors: Target for new analgesics? Eur. J. Pharmacol. 2011, 658, 49–56. [Google Scholar] [CrossRef] [PubMed]
  6. Tang, Y.-R.; Wang, C.; Zhang, Z.; Peng, S. A new class of analgesic agents toward prostacyclin receptor inhibition: Synthesis, Biological studies and QSAR analysis of 1-hydroxyl-2-substituted phenyl-4,4,5,5-tetramethylimidazolines. Eur. J. Med. Chem. 2008, 43, 1048–1058. [Google Scholar]
  7. Kahlon, D.K.; Lansdell, T.A.; Fisk, J.S.; Hupp, C.D.; Friebe, T.L.; Hovde, S.; Jones, A.D.; Dyer, R.D.; Henry, R.W.; Tepe, J.J. Nuclear Factor-кβ Mediated Inhibition of Cytokine Production by Imidazoline Scaffolds. J. Med. Chem. 2009, 52, 1302–1309. [Google Scholar] [CrossRef] [PubMed]
  8. Merriman, G.H.; Ma, L.; Shum, P.; McGarry, D.; Volz, F.; Sabol, J.S.; Gross, A.; Zhao, Z.; Rampe, D.; Wang, L.; et al. Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists. Bioorg. Chem. Med. Lett. 2005, 15, 435–438. [Google Scholar] [CrossRef] [PubMed]
  9. Cannon, J.S.; Frederich, J.H.; Overman, L.E. Palladacyclic Imidazoline−Naphthalene Complexes: Synthesis and Catalytic Performance in Pd(II)-Catalyzed Enantioselective Reactions of Allylic Trichloroacetimidates. J. Org. Chem. 2012, 77, 1939–1951. [Google Scholar] [CrossRef] [PubMed]
  10. Yuan, Z.; Mei, L.; Wei, Y.; Shi, M.; Kattamuri, P.V.; McDowell, P.; Li, G. Asymmetric catalytic Mannich-type reaction of hydrazones with difluoroenoxysilanes using imidazoline-anchored phosphine ligand–zinc(II) complexes. Org. Biomol. Chem. 2012, 10, 2509–2513. [Google Scholar] [CrossRef] [PubMed]
  11. Parra-Hake, M.; Larter, M.L.; Gantzel, P.; Aguirre, G.; Ortega, F.; Somanathan, R.; Walsh, P.J. Synthesis and Structure of Dimeric [(cis-Py3Im)M]2 Complexes [M = Ni, Cu, Zn; (cis-Py3Im) = cis-2,4,5-Tri(2-pyridyl)imidazoline]. Inorg. Chem. 2000, 39, 5400–5403. [Google Scholar] [CrossRef] [PubMed]
  12. Nolan, S.P. (Ed.) N-Heterocyclic Carbenes in Synthesis; Wiley-VCH: Weinheim, Germany, 2006. [Google Scholar]
  13. Benhamou, L.; Chardon, E.; Lavigne, G.; Bellemin-Laponnaz, S.; César, V. Synthetic Routes to N-Heterocyclic Carbene Precursors. Chem. Rev. 2011, 111, 2705–2733. [Google Scholar] [CrossRef] [PubMed]
  14. Neef, G.; Eder, U.; Sauer, G. One-step conversions of esters to 2-imidazolines, benzimidazoles and benzothiazoles by aluminum organic reagents. J. Org. Chem. 1981, 46, 2824–2826. [Google Scholar] [CrossRef]
  15. Chitwood, H.C.; Reid, E.E. Some Alkyl-glyoxalidines. J. Am. Chem. Soc. 1935, 57, 2424–2426. [Google Scholar] [CrossRef]
  16. Dauwe, C.; Buddrus, J. Synthesis of Enantiopure C2-Chiral Amidines. Synthesis 1995, 171–172. [Google Scholar] [CrossRef]
  17. Paliakov, E.; Elleboe, T.; Boykin, W.D. New Synthons for the Preparation of Arylimidazolines and Tetrahydropyrimidine Analogues. Synthesis 2007, 1475–1480. [Google Scholar] [CrossRef]
  18. Boland, N.A.; Casey, M.; Hynes, S.J.; Matthews, J.W.; Smyth, M.P. A Novel General Route for the Preparation of Enantiopure Imidazolines. J. Org. Chem. 2002, 67, 3919–3922. [Google Scholar] [CrossRef] [PubMed]
  19. Bender, H.S.; Heine, H.W. The Isomerization of Some Aziridine Derivatives. III. A New Synthesis of 2-Imidazolines. J. Org. Chem. 1960, 25, 461–463. [Google Scholar]
  20. Kuszpit, M.R.; Wulff, W.D.; Tepe, J.J. One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines. J. Org. Chem. 2011, 76, 2913–2919. [Google Scholar] [CrossRef] [PubMed]
  21. Elders, N.; Ruijter, E.; de Kanter, F.J.J.; Groen, M.B.; Orru, R.V.A. Selective Formation of 2-Imidazolines and 2-Substituted Oxazoles by Using a Three-Component Reaction. Chem. Eur. J. 2008, 14, 4961–4973. [Google Scholar] [CrossRef] [PubMed]
  22. Strassberger, Z.; Mooijman, M.; Ruijter, E.; Alberts, A.H.; de Graaff, C.; Orru, R.V.A.; Rothenberg, G. A Facile Route to Ruthenium-Carbene Complexes and their Application in Furfural Hydrogenation. Appl. Organomet. Chem. 2010, 24, 142–146. [Google Scholar]
  23. Aydin, J.; Kumar, K.S.; Eriksson, L.; Szabó, K.J. Palladium Pincer Complex-Catalyzed Condensation of Sulfonimines and Isocyanoacetate to Imidazoline Derivatives. Dependence of the Stereoselectivity on the Ligand Effects. Adv. Synth. Catal. 2007, 349, 2585–2594. [Google Scholar] [CrossRef]
  24. Bowman, R.K.; Johnson, J.S. Lewis Acid Catalyzed Dipolar Cycloadditions of an Activated Imidate. J. Org. Chem. 2004, 69, 8537–8540. [Google Scholar] [CrossRef] [PubMed]
  25. Worrall, K.; Xu, B.; Bontemps, S.; Arndtsen, B.A. A Palladium-Catalyzed Multicomponent Synthesis of Imidazolinium Salts and Imidazolines from Imines, Acid Chlorides, and Carbon Monoxide. J. Org. Chem. 2011, 76, 170–180. [Google Scholar] [CrossRef] [PubMed]
  26. Bontemps, S.; Quesnel, J.S.; Worrall, K.; Arndtsen, B.A. Palladium-Catalyzed Aryl Iodide Carbonylation as a Route to Imidazoline Synthesis: Design of a Five-Component Coupling Reaction. Angew. Chem. Int. Ed. 2011, 50, 8949–8951. [Google Scholar] [CrossRef] [PubMed]
  27. Dhawan, R.; Dghaym, R.D.; St. Cyr, D.J.; Arndtsen, B.A. Direct, Palladium-Catalyzed, Multicomponent Synthesis of β-Lactams from Imines, Acid Chloride, and Carbon Monoxide. Org. Lett. 2006, 8, 3927–3930. [Google Scholar] [CrossRef] [PubMed]
  28. Balme, G.; Bouyssi, D.; Monteiro, N. Metal-Catalyzed Multicomponent Reactions. In Multicomponent Reactions; Zhu, J., Bienayme, H., Eds.; Wiley-VCH: Weinheim, Germany, 2005; pp. 224–276. [Google Scholar]
  29. D’Souza, D.M.; Müller, T.J.J. Multi-component syntheses of heterocycles by transition-metal catalysis. Chem. Soc. Rev. 2007, 37, 1095–1108. [Google Scholar] [CrossRef] [PubMed]
  30. Arndtsen, B.A. Metal-Catalyzed One-Step Synthesis: Towards Direct Alternatives to Multistep Heterocycle and Amino Acid Derivative Formation. Chem. Eur. J. 2009, 15, 302–313. [Google Scholar] [CrossRef] [PubMed]
  31. Siamaki, A.R.; Black, D.A.; Arndtsen, B.A. Palladium-Catalyzed Carbonylative Cross-Coupling with Imines: A Multicomponent Synthesis of Imidazolones. J. Org. Chem. 2008, 73, 1135–1138. [Google Scholar] [CrossRef] [PubMed]
  32. Black, D.A.; Arndtsen, B.A. Copper-Catalyzed Cross-Coupling of Imines, Acid Chlorides, and Organostannanes: A Multicomponent Synthesis of α-Substituted Amides. J. Org. Chem. 2005, 70, 5133–5138. [Google Scholar] [CrossRef] [PubMed]
  33. Black, D.A.; Arndtsen, B.A. General Approach to the Coupling of Organoindium Reagents with Imines via Copper Catalysis. Org. Lett. 2006, 8, 1991–1993. [Google Scholar] [CrossRef] [PubMed]
  34. Gotthardt, H.; Hüisgen, R.; Schaefer, F.C. Δ2-pyrroline aus mesoionischen oxazolen und olefinen. Tetrahedron Lett. 1964, 5, 487–491. [Google Scholar] [CrossRef]
  35. Gotthardt, H.; Hüisgen, R. 1.3-Dipolare Cycloaddition, LVII. Δ2-Pyrroline aus N-substituierten Oxazolium-5-oxiden und olefinischen Dipolarophilen. Chem. Ber. 1970, 103, 2625–2638. [Google Scholar] [CrossRef]
  36. Qu, K.; Fisk, J.S.; Tepe, J.J. Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: Converting trans- to its cis-imidazolines. Tetrahedron Lett. 2011, 52, 4840–4842. [Google Scholar] [CrossRef] [PubMed]
  37. The relative stereochemistry of trans-2a and cis-2a was verified debenzylation of these compounds and comparing the resulting imidazolines to known literature compounds. The identity of imidazolium 3a was verified by synthesizing an authentic sample via the benzylation of imidazole. See supporting information for details.
  38. Layer, R.W. The Chemistry of Imines. Chem. Rev. 1963, 63, 489–510. [Google Scholar] [CrossRef]
  39. Dhawan, R.; Dghaym, R.D.; Arndtsen, B.A. The Development of a Catalytic Synthesis of Münchnones: A Simple Four-Component Coupling Approach to α-Amino Acid Derivatives. J. Am. Chem. Soc. 2003, 125, 1474–1475. [Google Scholar] [CrossRef] [PubMed]
  40. Wang, F.; Liao, Q.; Xi, C. Convenient One-Step Synthesis of cis-2,4,5-Triarylimidazolines from Aromatic Aldehydes with Urea. Synth. Commun. 2012, 42, 905–913. [Google Scholar] [CrossRef]
  41. The parent imidazole was synthesized according to: Siamaki, A.R.; Arndtsen, B.A. A Direct, One Step Synthesis of Imidazoles from Imines and Acid Chlorides: A Palladium Catalyzed Multicomponent Coupling Approach. J. Am. Chem. Soc. 2006, 128, 6050–6051. [Google Scholar] [CrossRef] [PubMed]
Sample Availability: Not Available.
Scheme 1. Palladium catalyzed synthesis of imidazolinium carboxylates.
Scheme 1. Palladium catalyzed synthesis of imidazolinium carboxylates.
Molecules 17 13759 sch001
Scheme 2. Thermal decarboxylation of imidazolinium carboxylates.
Scheme 2. Thermal decarboxylation of imidazolinium carboxylates.
Molecules 17 13759 sch002
Scheme 3. Nitrogen deprotection of imidazolines.
Scheme 3. Nitrogen deprotection of imidazolines.
Molecules 17 13759 sch003
Scheme 4. Modular synthesis of imidazolines.
Scheme 4. Modular synthesis of imidazolines.
Molecules 17 13759 sch004
Table 1. Influence of acids on the generation of imidazolinium salts.
Table 1. Influence of acids on the generation of imidazolinium salts.
Molecules 17 13759 i001
EntryAcidYield 2atrans : cis 2a
1 Molecules 17 13759 i00278%3.2:1
2 Molecules 17 13759 i00378%2.7:1
3 Molecules 17 13759 i00487%2.7:1
4HCl- a-
5 Molecules 17 13759 i005- a-
6 Molecules 17 13759 i006- a-
7 Molecules 17 13759 i00724%1.5:1
8 Molecules 17 13759 i00886%20:1
9H2O (20 equiv.)- b-
Reaction conditions: 1a (0.1 mmol) and acid (0.1 mmol) in 5 mL CHCl3 heated at 65 °C for 6 h. Yields determined by 1H-NMR relative to a benzyl benzoate internal standard. a Recovery of protonated starting material. b Decomposition of starting material.

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Xu, B.; Worrall, K.; Arndtsen, B.A. Palladium-Catalyzed Multicomponent Synthesis of 2-Imidazolines from Imines and Acid Chlorides. Molecules 2012, 17, 13759-13768. https://doi.org/10.3390/molecules171213759

AMA Style

Xu B, Worrall K, Arndtsen BA. Palladium-Catalyzed Multicomponent Synthesis of 2-Imidazolines from Imines and Acid Chlorides. Molecules. 2012; 17(12):13759-13768. https://doi.org/10.3390/molecules171213759

Chicago/Turabian Style

Xu, Boran, Kraig Worrall, and Bruce A. Arndtsen. 2012. "Palladium-Catalyzed Multicomponent Synthesis of 2-Imidazolines from Imines and Acid Chlorides" Molecules 17, no. 12: 13759-13768. https://doi.org/10.3390/molecules171213759

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