Molecules 2012, 17(11), 13235-13252; doi:10.3390/molecules171113235
Review

Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles

1, 1, 1, 1, 2, 3, 4, 5 and 1,* email
Received: 19 September 2012; in revised form: 29 October 2012 / Accepted: 1 November 2012 / Published: 6 November 2012
(This article belongs to the Special Issue Transition Metals Catalysis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block copolymer (DHBC) nanoreactors and ZnO–CuO hybrid NPs were synthesized. Non-conventional energy sources such as microwaves and ultrasound were also applied to these click reactions, and good catalytic activity with high regioselectivity was observed. CuO hollow NPs on acetylene black can be recycled nine times without any loss of activity, and water-soluble DHBC nanoreactors have been developed for an environmentally friendly process.
Keywords: copper oxide; nanocatalyst; heterogeneous; hybrid; click reaction
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MDPI and ACS Style

Woo, H.; Kang, H.; Kim, A.; Jang, S.; Park, J.C.; Park, S.; Kim, B.-S.; Song, H.; Park, K.H. Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles. Molecules 2012, 17, 13235-13252.

AMA Style

Woo H, Kang H, Kim A, Jang S, Park JC, Park S, Kim B-S, Song H, Park KH. Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles. Molecules. 2012; 17(11):13235-13252.

Chicago/Turabian Style

Woo, Hyunje; Kang, Hyuntae; Kim, Aram; Jang, Seongwan; Park, Ji C.; Park, Sungkyun; Kim, Byeong-Su; Song, Hyunjoon; Park, Kang H. 2012. "Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles." Molecules 17, no. 11: 13235-13252.


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