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Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles
Department of Chemistry, Chemistry Institute for Functional Materials, Pusan National University, Busan 609-735, Korea
Clean Fuel Department, Korea Institute of Energy Research, Daejeon 305-343, Korea
Department of Physics, Pusan National University, Busan 609-735, Korea
Interdisciplinary School of Green Energy and School of NanoBioscience and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), 100 Banyeon-ri, Ulsan 689-798, Korea
Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
* Author to whom correspondence should be addressed.
Received: 19 September 2012; in revised form: 29 October 2012 / Accepted: 1 November 2012 / Published: 6 November 2012
Abstract: Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block copolymer (DHBC) nanoreactors and ZnO–CuO hybrid NPs were synthesized. Non-conventional energy sources such as microwaves and ultrasound were also applied to these click reactions, and good catalytic activity with high regioselectivity was observed. CuO hollow NPs on acetylene black can be recycled nine times without any loss of activity, and water-soluble DHBC nanoreactors have been developed for an environmentally friendly process.
Keywords: copper oxide; nanocatalyst; heterogeneous; hybrid; click reaction
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Woo, H.; Kang, H.; Kim, A.; Jang, S.; Park, J.C.; Park, S.; Kim, B.-S.; Song, H.; Park, K.H. Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles. Molecules 2012, 17, 13235-13252.
Woo H, Kang H, Kim A, Jang S, Park JC, Park S, Kim B-S, Song H, Park KH. Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles. Molecules. 2012; 17(11):13235-13252.
Woo, Hyunje; Kang, Hyuntae; Kim, Aram; Jang, Seongwan; Park, Ji C.; Park, Sungkyun; Kim, Byeong-Su; Song, Hyunjoon; Park, Kang H. 2012. "Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles." Molecules 17, no. 11: 13235-13252.