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Molecules 2012, 17(11), 13662-13672; doi:10.3390/molecules171113662
Article

Beckmann Rearrangement of Ketoximes Induced by Phenyl Dichlorophosphate at Ambient Temperature

1,2, 3, 2, 1, 2 and 1,*
1 Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan 2 Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan 3 Chinese Medicinal Research and Development Center, China Medical University Hospital, 2 Yude Road, Taichung 40447, Taiwan
* Author to whom correspondence should be addressed.
Received: 21 September 2012 / Revised: 12 November 2012 / Accepted: 14 November 2012 / Published: 20 November 2012
(This article belongs to the Section Organic Synthesis)
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Abstract

Upon treatment with phenyl dichlorophosphate (PhOP=OCl2) in acetonitrile at ambient temperature, a variety of ketoximes underwent a Beckmann rearrangement in an effective manner to afford the corresponding amides in moderate to high yields.
Keywords: Beckmann rearrangement; phenyl dichlorophosphate; ketoximes; ambient temperature Beckmann rearrangement; phenyl dichlorophosphate; ketoximes; ambient temperature
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kuo, C.-W.; Hsieh, M.-T.; Gao, S.; Shao, Y.-M.; Yao, C.-F.; Shia, K.-S. Beckmann Rearrangement of Ketoximes Induced by Phenyl Dichlorophosphate at Ambient Temperature. Molecules 2012, 17, 13662-13672.

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