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Molecules 2012, 17(11), 13656-13661; doi:10.3390/molecules171113656
Article

Clerodendranoic Acid, a New Phenolic Acid from Clerodendranthus spicatus

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Received: 1 November 2012 / Revised: 13 November 2012 / Accepted: 14 November 2012 / Published: 19 November 2012
(This article belongs to the Section Metabolites)
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Abstract

Phenolic acid derivatives are typical constituents of Clerodendranthus spicatus which were considered to the active principles of this medicinal plant. These chemical constituents with their interesting frameworks and biological significance attracted our attention. As part of our ongoing chemical investigation of C. spicatus using various column chromatography techniques, a new phenolic compound, named clerodendranoic acid (1), was isolated from the aerial parts of C. spicatus together with five known ones, including rosmarinic acid (2), methyl rosmarinate (3), caffeic acid (4), methyl caffeate (5), ethyl caffeate (6). Their structures, including stereochemical configurations, were completely established by extensive spectroscopic methods, mainly inclvolving 1D, 2D NMR, as well as HRESIMS.
Keywords: Clerodendranthus spicatus; Lamiaceae; phenolic compounds Clerodendranthus spicatus; Lamiaceae; phenolic compounds
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zheng, Q.; Sun, Z.; Zhang, X.; Yuan, J.; Wu, H.; Yang, J.; Xu, X. Clerodendranoic Acid, a New Phenolic Acid from Clerodendranthus spicatus. Molecules 2012, 17, 13656-13661.

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