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• Zheng, Q
• Sun, Z
• Zhang, X
• Yuan, J
• Wu, H
• Yang, J
• Xu, X
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• Zheng, Q
• Sun, Z
• Zhang, X
• Yuan, J
• Wu, H
• Yang, J
• Xu, X
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• Sun, Z
• Zhang, X
• Yuan, J
• Wu, H
• Yang, J
• Xu, X

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Molecules 2012, 17(11), 13656-13661; doi:10.3390/molecules171113656

Article

Clerodendranoic Acid, a New Phenolic Acid from Clerodendranthus spicatus

Qingxia Zheng ^1,† , Zhaocui Sun ^1,† , Xiaopo Zhang ¹ , Jinquan Yuan ² , Haifeng Wu ¹ , Junshan Yang ¹  and Xudong Xu ^1,*

¹ Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China ² National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, National Development and Reform Commission, Guangxi Botanical Garden of Medicinal Plant, Nanning 530023, China ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 1 November 2012; in revised form: 13 November 2012 / Accepted: 14 November 2012 / Published: 19 November 2012

(This article belongs to the Section Natural Products)

Download PDF Full-Text [216 KB, uploaded 19 November 2012 11:02 CET]

Abstract: Phenolic acid derivatives are typical constituents of Clerodendranthus spicatus which were considered to the active principles of this medicinal plant. These chemical constituents with their interesting frameworks and biological significance attracted our attention. As part of our ongoing chemical investigation of C. spicatus using various column chromatography techniques, a new phenolic compound, named clerodendranoic acid (1), was isolated from the aerial parts of C. spicatus together with five known ones, including rosmarinic acid (2), methyl rosmarinate (3), caffeic acid (4), methyl caffeate (5), ethyl caffeate (6). Their structures, including stereochemical configurations, were completely established by extensive spectroscopic methods, mainly inclvolving 1D, 2D NMR, as well as HRESIMS.

Keywords: Clerodendranthus spicatus; Lamiaceae; phenolic compounds

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