Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2

doi:10.3390/molecules171113175

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Molecules 2012, 17(11), 13175-13182; doi:10.3390/molecules171113175

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Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2

Rong Wang^†, Tian-Mi Liu^†, Ming-Hui Shen, Ming-Qiu Yang, Quan-Ying Feng, Xian-Ming Tang and Xiang-Min Li*

Hainan Provincial Fisheries Research Institute, Haikou 570203, Hainan, China ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 18 October 2012; in revised form: 30 October 2012 / Accepted: 31 October 2012 / Published: 5 November 2012

(This article belongs to the Section Natural Products)

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Abstract: Three new γ-butenolide derivatives 1–3, named spiculisporic acids B–D, were isolated from the culture of Aspergillus sp. HDf2, a marine-derived fungus that resides in the sea urchin, Anthocidaris crassispina. The structures of 1–3 were elucidated on the basis of spectroscopic methods, including MS and 2D NMR techniques. Their in vitro cytotoxic activities against two cell lines (SGC-7901, human gastric adenocarcinoma and SPC-A-1, human lung adenocarcinoma) and inhibitory activities against Staphylococcus aureus ATCC 51650 were investigated.

Keywords: γ-butenolide derivatives; spiculisporic acids B–D; Aspergillus sp.; marine fungus

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Cite This Article

MDPI and ACS Style

Wang, R.; Liu, T.-M.; Shen, M.-H.; Yang, M.-Q.; Feng, Q.-Y.; Tang, X.-M.; Li, X.-M. Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2. Molecules 2012, 17, 13175-13182.

AMA Style

Wang R, Liu T-M, Shen M-H, Yang M-Q, Feng Q-Y, Tang X-M, Li X-M. Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2. Molecules. 2012; 17(11):13175-13182.

Chicago/Turabian Style

Wang, Rong; Liu, Tian-Mi; Shen, Ming-Hui; Yang, Ming-Qiu; Feng, Quan-Ying; Tang, Xian-Ming; Li, Xiang-Min. 2012. "Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2." Molecules 17, no. 11: 13175-13182.

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