Two New Cholic Acid Derivatives from the Marine Ascidian-Associated Bacterium Hasllibacter halocynthiae

doi:10.3390/molecules171012357

This article is

freely available
re-usable

Molecules 2012, 17(10), 12357-12364; doi:10.3390/molecules171012357

Article

Two New Cholic Acid Derivatives from the Marine Ascidian-Associated Bacterium Hasllibacter halocynthiae

Sung Hun Kim^1,2, Yun Kyung Shin³, Young Chang Sohn² and Hak Cheol Kwon^1,*

¹ Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung 210-340, Korea ² Division of Applied Marine Biotechnology and Engineering, Faculty of Marine Bioscience and Technology, Gangneung-Wonju National University, Gangneung 210-702, Korea ³ Aquaculture Management Division, National Fisheries Research and Development Institute, Busan 619-705, Korea

* Author to whom correspondence should be addressed.

Received: 13 August 2012; in revised form: 8 October 2012 / Accepted: 17 October 2012 / Published: 22 October 2012

(This article belongs to the Section Natural Products)

Download PDF Full-Text [251 KB, uploaded 22 October 2012 11:25 CEST]

Abstract: The investigation of secondary metabolites in liquid cultures of a recently discovered marine bacterium, Hasllibacter halocynthiae strain KME 002^T, led to the isolation of two new cholic acid derivatives. The structures of these compounds were determined to be 3,3,12-trihydroxy-7-ketocholanic acid (1) and 3,3,12-trihydroxy-7-deoxycholanic acid (2) through HRFABMS and NMR data analyses.

Keywords: Hasllibacter halocynthiae; cholic acids; cholanic acid ketal; marine ascidian

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Kim, S.H.; Shin, Y.K.; Sohn, Y.C.; Kwon, H.C. Two New Cholic Acid Derivatives from the Marine Ascidian-Associated Bacterium Hasllibacter halocynthiae. Molecules 2012, 17, 12357-12364.

AMA Style

Kim SH, Shin YK, Sohn YC, Kwon HC. Two New Cholic Acid Derivatives from the Marine Ascidian-Associated Bacterium Hasllibacter halocynthiae. Molecules. 2012; 17(10):12357-12364.

Chicago/Turabian Style

Kim, Sung Hun; Shin, Yun Kyung; Sohn, Young Chang; Kwon, Hak Cheol. 2012. "Two New Cholic Acid Derivatives from the Marine Ascidian-Associated Bacterium Hasllibacter halocynthiae." Molecules 17, no. 10: 12357-12364.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert