Molecules 2012, 17(1), 98-144; doi:10.3390/molecules17010098
Review

Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics

1, 2, 3 and 1,* email
Received: 4 November 2011; in revised form: 5 December 2011 / Accepted: 14 December 2011 / Published: 23 December 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The purpose of this review is to compile preclinical and clinical results on phthalocyanines (Pcs) as photosensitizers (PS) for Photodynamic Therapy (PDT) and contrast agents for fluorescence imaging. Indeed, Pcs are excellent candidates in these fields due to their strong absorbance in the NIR region and high chemical and photo-stability. In particular, this is mostly relevant for their in vivo activation in deeper tissular regions. However, most Pcs present two major limitations, i.e., a strong tendency to aggregate and a low water-solubility. In order to overcome these issues, both chemical tuning and pharmaceutical formulation combined with tumor targeting strategies were applied. These aspects will be developed in this review for the most extensively studied Pcs during the last 25 years, i.e., aluminium-, zinc- and silicon-based Pcs.
Keywords: biomedical optics; fluorescence diagnosis; phthalocyanines; NIR dyes; photodynamic therapy
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MDPI and ACS Style

Sekkat, N.; Bergh, H.; Nyokong, T.; Lange, N. Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics. Molecules 2012, 17, 98-144.

AMA Style

Sekkat N, Bergh H, Nyokong T, Lange N. Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics. Molecules. 2012; 17(1):98-144.

Chicago/Turabian Style

Sekkat, Nawal; Bergh, Hubert van den; Nyokong, Tebello; Lange, Norbert. 2012. "Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics." Molecules 17, no. 1: 98-144.


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