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Molecules 2012, 17(1), 664-673; doi:10.3390/molecules17010664
Article

Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568

1,2, 1,2, 1,2, 2, 2,3,*  and 1,*
Received: 21 November 2011; in revised form: 6 January 2012 / Accepted: 6 January 2012 / Published: 11 January 2012
(This article belongs to the Section Metabolites)
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Abstract: A new azaphilonidal derivative, monapurpyridine A (MPA), has recently been isolated from the fermented products of Monascus purpureus NTU 568. The structure of MPA was elucidated by nuclear magnetic resonance (1H-NMR, 13C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Biological evaluation revealed that MPA could induce cell death in human breast adenocarcinoma cells MCF-7, and it has no significant toxicity to normal mammary epithelial cells M10. The MTT assay and flow cytometric analysis were employed to investigate cell viability and cell cycle influenced by MPA. Moreover, we used Western blot and caspase activity assay to demonstrate the activation of caspase-3, -8 and -9 resulted from MPA. All evidence supported that MPA was suitable for developing into a chemotherapeutic or chemopreventive agent against breast cancer.
Keywords: Monascus purpureus NTU 568; azaphilone; monapurpyridine A; cytotoxicity; apoptosis Monascus purpureus NTU 568; azaphilone; monapurpyridine A; cytotoxicity; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hsu, L.-C.; Hsu, Y.-W.; Liang, Y.-H.; Liaw, C.-C.; Kuo, Y.-H.; Pan, T.-M. Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568. Molecules 2012, 17, 664-673.

AMA Style

Hsu L-C, Hsu Y-W, Liang Y-H, Liaw C-C, Kuo Y-H, Pan T-M. Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568. Molecules. 2012; 17(1):664-673.

Chicago/Turabian Style

Hsu, Li-Chuan; Hsu, Ya-Wen; Liang, Yu-Han; Liaw, Chia-Ching; Kuo, Yao-Haur; Pan, Tzu-Ming. 2012. "Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568." Molecules 17, no. 1: 664-673.


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