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Molecules 2012, 17(1), 664-673; doi:10.3390/molecules17010664

Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568

1
Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan
2
Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 11221, Taiwan
3
Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 21 November 2011 / Revised: 6 January 2012 / Accepted: 6 January 2012 / Published: 11 January 2012
(This article belongs to the Section Natural Products)
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Abstract

A new azaphilonidal derivative, monapurpyridine A (MPA), has recently been isolated from the fermented products of Monascus purpureus NTU 568. The structure of MPA was elucidated by nuclear magnetic resonance (1H-NMR, 13C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Biological evaluation revealed that MPA could induce cell death in human breast adenocarcinoma cells MCF-7, and it has no significant toxicity to normal mammary epithelial cells M10. The MTT assay and flow cytometric analysis were employed to investigate cell viability and cell cycle influenced by MPA. Moreover, we used Western blot and caspase activity assay to demonstrate the activation of caspase-3, -8 and -9 resulted from MPA. All evidence supported that MPA was suitable for developing into a chemotherapeutic or chemopreventive agent against breast cancer.
Keywords: Monascus purpureus NTU 568; azaphilone; monapurpyridine A; cytotoxicity; apoptosis Monascus purpureus NTU 568; azaphilone; monapurpyridine A; cytotoxicity; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hsu, L.-C.; Hsu, Y.-W.; Liang, Y.-H.; Liaw, C.-C.; Kuo, Y.-H.; Pan, T.-M. Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568. Molecules 2012, 17, 664-673.

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