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A New Prenylated Flavanone from Derris trifoliata Lour.
Department of Pharmacy, Medical College, Hunan Normal University, Changsha 410006, China
Key Laboratory of Marine Bio-resourses Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 30 October 2011; in revised form: 26 December 2011 / Accepted: 27 December 2011 / Published: 11 January 2012
Abstract: A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro-rotenone, dehydrodeguelin, 7a-O-methyldeguelol, 7a-O-methylelliptonol, 5,7,3',4'-tetra-hydroxy-6,8-diprenylisoflavone, daidzein and 4'-hydroxy-7-methoxyflavanone. 7a-O-Methylelliptonol was isolated for the first time from the genus Derris. Their structures were characterized on the basis of spectral data. Eight of the isolated compounds were found to be significantly toxic to brine shrimp (LC50 range 0.06–9.95 μg/mL). The new compound showed weak toxicity (LC50 = 211.31 μg/mL).
Keywords: Derris trifoliate; aerial part; prenylated flavanone; rotenoids; brine shrimp toxicity
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MDPI and ACS Style
Jiang, C.; Liu, S.; He, W.; Luo, X.; Zhang, S.; Xiao, Z.; Qiu, X.; Yin, H. A New Prenylated Flavanone from Derris trifoliata Lour.. Molecules 2012, 17, 657-663.
Jiang C, Liu S, He W, Luo X, Zhang S, Xiao Z, Qiu X, Yin H. A New Prenylated Flavanone from Derris trifoliata Lour.. Molecules. 2012; 17(1):657-663.
Jiang, Cheng; Liu, Shengzi; He, Weihong; Luo, Xiongming; Zhang, Si; Xiao, Zhihui; Qiu, Ximin; Yin, Hao. 2012. "A New Prenylated Flavanone from Derris trifoliata Lour.." Molecules 17, no. 1: 657-663.