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Molecules 2012, 17(1), 657-663; doi:10.3390/molecules17010657
Article

A New Prenylated Flavanone from Derris trifoliata Lour.

1,†
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1,†
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2, 2
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2
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2
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1,*  and 2,*
1 Department of Pharmacy, Medical College, Hunan Normal University, Changsha 410006, China 2 Key Laboratory of Marine Bio-resourses Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 30 October 2011 / Revised: 26 December 2011 / Accepted: 27 December 2011 / Published: 11 January 2012
(This article belongs to the Section Metabolites)
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Abstract

A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro-rotenone, dehydrodeguelin, 7a-O-methyldeguelol, 7a-O-methylelliptonol, 5,7,3',4'-tetra-hydroxy-6,8-diprenylisoflavone, daidzein and 4'-hydroxy-7-methoxyflavanone. 7a-O-Methylelliptonol was isolated for the first time from the genus Derris. Their structures were characterized on the basis of spectral data. Eight of the isolated compounds were found to be significantly toxic to brine shrimp (LC50 range 0.06–9.95 μg/mL). The new compound showed weak toxicity (LC50 = 211.31 μg/mL).
Keywords: Derris trifoliate; aerial part; prenylated flavanone; rotenoids; brine shrimp toxicity Derris trifoliate; aerial part; prenylated flavanone; rotenoids; brine shrimp toxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jiang, C.; Liu, S.; He, W.; Luo, X.; Zhang, S.; Xiao, Z.; Qiu, X.; Yin, H. A New Prenylated Flavanone from Derris trifoliata Lour.. Molecules 2012, 17, 657-663.

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