Next Article in Journal
Enzyme Treatment-Free and Ligation-Independent Cloning Using Caged Primers in Polymerase Chain Reactions
Previous Article in Journal
Enantiomeric Separation and Determination of the Enantiomeric Impurity of Armodafinil by Capillary Electrophoresis with Sulfobutyl Ether-β-cyclodextrin as Chiral Selector
Molecules 2012, 17(1), 315-327; doi:10.3390/molecules17010315
Article

Neuroprotective Effects of Exogenous Activin A on Oxygen-Glucose Deprivation in PC12 Cells

1
, 1
, 1,2
, 3
, 1
, 1
, 1
 and 1,*
Received: 6 December 2011; in revised form: 19 December 2011 / Accepted: 22 December 2011 / Published: 30 December 2011
(This article belongs to the Section Medicinal Chemistry)
Download PDF [422 KB, uploaded 18 June 2014]
Abstract: Ischemic cerebrovascular disease is one of the most common causes of death in the World. Exogenous activin A (ActA) protects neurons against toxicity and plays a central role in regulating the brain’s response to injury. In the present study, we investigated the mechanisms involved in the neuroprotective effects of ActA in a model of hypoxic-ischemic brain disease. We found that ActA could effectively increase the survival rate of PC12 cells and relieve oxygen-glucose deprivation (OGD) damage. To clarify the neuroprotective mechanisms of ActA, the effects of ActA on the ActA/Smad pathway and on the up-regulation of inducible nitric oxide synthase (NOS) and superoxide dismutase (SOD) were investigated using OGD in PC12 cells. The results showed that ActA could increase the expression of activin receptor IIA (ActRIIA), Smad3 and Smad4 and that 50 ng/mL and 100 ng/mL of ActA could reduce NO levels and increase SOD activity by 78.9% and 79.9%, respectively. These results suggested that the neuroprotective effects of ActA in ischemia could be related to the activation of the ActA/Smad signaling pathway and to its anti-oxidant activities.
Keywords: OGD; tolerance model; exogenous activin A OGD; tolerance model; exogenous activin A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

He, J.-T.; Mang, J.; Mei, C.-L.; Yang, L.; Wang, J.-Q.; Xing, Y.; Yang, H.; Xu, Z.-X. Neuroprotective Effects of Exogenous Activin A on Oxygen-Glucose Deprivation in PC12 Cells. Molecules 2012, 17, 315-327.

AMA Style

He J-T, Mang J, Mei C-L, Yang L, Wang J-Q, Xing Y, Yang H, Xu Z-X. Neuroprotective Effects of Exogenous Activin A on Oxygen-Glucose Deprivation in PC12 Cells. Molecules. 2012; 17(1):315-327.

Chicago/Turabian Style

He, Jin-Ting; Mang, Jing; Mei, Chun-Li; Yang, Le; Wang, Jiao-Qi; Xing, Ying; Yang, Hong; Xu, Zhong-Xin. 2012. "Neuroprotective Effects of Exogenous Activin A on Oxygen-Glucose Deprivation in PC12 Cells." Molecules 17, no. 1: 315-327.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert