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Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts
Department of Pharmaceutical Research and Development, Institute for Medicinal Plant Research "Dr Josif Pančić", Tadeuša Košćuška 1, 11 000 Belgrade, Serbia
Department of Pharmacy, Faculty of Medicine, University of Niš, Dr Zoran Đinđić Boulevard 81, Niš, Serbia
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Belgade, Bulevar oslobođenja 18, 11 000 Belgrade, Serbia
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, Vojvode Stepe 450, 11 000 Belgrade, Serbia
* Author to whom correspondence should be addressed.
Received: 4 November 2011; in revised form: 30 November 2011 / Accepted: 16 December 2011 / Published: 28 December 2011
Abstract: Oleum Hyperici, the oil extract of St. John’s Wort (SJW), is one of the oldest folk remedies, traditionally used in the topical treatment of wounds, bruises, ulcers, cuts, burns, hemorrhoids and also as an antiseptic. Considering the advantageous characteristics of emulsion applications, in the present study we have formulated three O/W creams containing 15% (w/v) of SJW oil extract as an active ingredient. The aim was to estimate dermatological application of the prepared creams for the abovementioned indications. The extracts were prepared according to the prescriptions from traditional medicine, however with different vegetable oils used as an extractant, namely: Olive, palm and sunflower oil. The investigated O/W creams demonstrated significant antiinflammatory effects in an in vivo double-blind randomized study, using a sodium lauryl sulphate test. Both skin parameters assessed in the study (electrical capacitance and erythema index), were restored to the baseline value after a seven-day treatment with the tested creams. Almost all investigated SJW oil extracts and corresponding creams displayed the same antimicrobial activity against the most of the investigated microorganisms with obtained minimal inhibitory concentrations values of 1,280 µg/mL, 2,560 µg/mL or >2,560 µg/mL.
Keywords: St. John’s Wort; oil extracts; sunflower, olive, palm oil; dermatological application
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Arsić, I.; Žugić, A.; Tadić, V.; Tasić-Kostov, M.; Mišić, D.; Primorac, M.; Runjaić-Antić, D. Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts. Molecules 2012, 17, 275-294.
Arsić I, Žugić A, Tadić V, Tasić-Kostov M, Mišić D, Primorac M, Runjaić-Antić D. Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts. Molecules. 2012; 17(1):275-294.
Arsić, Ivana; Žugić, Ana; Tadić, Vanja; Tasić-Kostov, Marija; Mišić, Dušan; Primorac, Marija; Runjaić-Antić, Dušanka. 2012. "Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts." Molecules 17, no. 1: 275-294.