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Molecules 2012, 17(1), 275-294; doi:10.3390/molecules17010275
Article

Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts

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Received: 4 November 2011; in revised form: 30 November 2011 / Accepted: 16 December 2011 / Published: 28 December 2011
(This article belongs to the Section Metabolites)
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Abstract: Oleum Hyperici, the oil extract of St. John’s Wort (SJW), is one of the oldest folk remedies, traditionally used in the topical treatment of wounds, bruises, ulcers, cuts, burns, hemorrhoids and also as an antiseptic. Considering the advantageous characteristics of emulsion applications, in the present study we have formulated three O/W creams containing 15% (w/v) of SJW oil extract as an active ingredient. The aim was to estimate dermatological application of the prepared creams for the abovementioned indications. The extracts were prepared according to the prescriptions from traditional medicine, however with different vegetable oils used as an extractant, namely: Olive, palm and sunflower oil. The investigated O/W creams demonstrated significant antiinflammatory effects in an in vivo double-blind randomized study, using a sodium lauryl sulphate test. Both skin parameters assessed in the study (electrical capacitance and erythema index), were restored to the baseline value after a seven-day treatment with the tested creams. Almost all investigated SJW oil extracts and corresponding creams displayed the same antimicrobial activity against the most of the investigated microorganisms with obtained minimal inhibitory concentrations values of 1,280 µg/mL, 2,560 µg/mL or >2,560 µg/mL.
Keywords: St. John’s Wort; oil extracts; sunflower, olive, palm oil; dermatological application St. John’s Wort; oil extracts; sunflower, olive, palm oil; dermatological application
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Arsić, I.; Žugić, A.; Tadić, V.; Tasić-Kostov, M.; Mišić, D.; Primorac, M.; Runjaić-Antić, D. Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts. Molecules 2012, 17, 275-294.

AMA Style

Arsić I, Žugić A, Tadić V, Tasić-Kostov M, Mišić D, Primorac M, Runjaić-Antić D. Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts. Molecules. 2012; 17(1):275-294.

Chicago/Turabian Style

Arsić, Ivana; Žugić, Ana; Tadić, Vanja; Tasić-Kostov, Marija; Mišić, Dušan; Primorac, Marija; Runjaić-Antić, Dušanka. 2012. "Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts." Molecules 17, no. 1: 275-294.


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