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Molecules 2012, 17(1), 267-274; doi:10.3390/molecules17010267
Article

Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)

1,* , 1
, 1
, 1
, 1, 1
, 2, 2
 and 3
1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan 3 Institut de Chimie de la Substances Naturelles, Centre Nationale de la Recherches Scientifique, 91198, Gif-sur Yvette, Cedex, France
* Author to whom correspondence should be addressed.
Received: 25 October 2011 / Revised: 19 December 2011 / Accepted: 26 December 2011 / Published: 28 December 2011
(This article belongs to the Section Metabolites)
Download PDF [305 KB, 18 June 2014; original version 18 June 2014]

Abstract

A new indole alkaloid; neonaucline (1), along with six known compounds–Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A–were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, 13C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 13 after injection of each sample at 1 × 10−5 M.
Keywords: Ochreinauclea maingayii; neonaucline; nauledine; cadamine; Rubiaceae; alkaloid Ochreinauclea maingayii; neonaucline; nauledine; cadamine; Rubiaceae; alkaloid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mukhtar, M.R.; Osman, N.; Awang, K.; Hazni, H.; Qureshi, A.K.; Hadi, A.H.A.; Zaima, K.; Morita, H.; Litaudon, M. Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae). Molecules 2012, 17, 267-274.

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