Molecules 2012, 17(1), 267-274; doi:10.3390/molecules17010267
Article

Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)

Mat Ropi Mukhtar 1,* email, Norfaizah Osman 1 email, Khalijah Awang 1 email, Hazrina Hazni 1 email, Ahmad Kaleem Qureshi 1 , A. Hamid A. Hadi 1 email, Kazuma Zaima 2 , Hiroshi Morita 2 email and Marc Litaudon 3 email
1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan 3 Institut de Chimie de la Substances Naturelles, Centre Nationale de la Recherches Scientifique, 91198, Gif-sur Yvette, Cedex, France
* Author to whom correspondence should be addressed.
Received: 25 October 2011; in revised form: 19 December 2011 / Accepted: 26 December 2011 / Published: 28 December 2011
(This article belongs to the Section Natural Products)
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Abstract: A new indole alkaloid; neonaucline (1), along with six known compounds–Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A–were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, 13C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1–3 after injection of each sample at 1 × 10−5 M.
Keywords: Ochreinauclea maingayii; neonaucline; nauledine; cadamine; Rubiaceae; alkaloid

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Cite This Article

MDPI and ACS Style

Mukhtar, M.R.; Osman, N.; Awang, K.; Hazni, H.; Qureshi, A.K.; Hadi, A.H.A.; Zaima, K.; Morita, H.; Litaudon, M. Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae). Molecules 2012, 17, 267-274.

AMA Style

Mukhtar MR, Osman N, Awang K, Hazni H, Qureshi AK, Hadi AHA, Zaima K, Morita H, Litaudon M. Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae). Molecules. 2012; 17(1):267-274.

Chicago/Turabian Style

Mukhtar, Mat Ropi; Osman, Norfaizah; Awang, Khalijah; Hazni, Hazrina; Qureshi, Ahmad Kaleem; Hadi, A. Hamid A.; Zaima, Kazuma; Morita, Hiroshi; Litaudon, Marc. 2012. "Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)." Molecules 17, no. 1: 267-274.

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