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Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil
Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil
Hospital de Clínicas de Porto Alegre, Serviço de Genética Médica, UFRGS, Porto Alegre, RS 93050-150, Brazil
* Author to whom correspondence should be addressed.
Received: 5 December 2011; in revised form: 27 December 2011 / Accepted: 9 January 2012 / Published: 23 January 2012
Abstract: Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.
Keywords: anti-inflammatory; antioxidant; Baccharis trimera; phenolic compounds; pleurisy; saponin; TAR
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de Oliveira, C.B.; Comunello, L.N.; Lunardelli, A.; Amaral, R.H.; Pires, M.G.S.; da Silva, G.L.; Manfredini, V.; Vargas, C.R.; Gnoatto, S.C.B.; de Oliveira, J.R.; Gosmann, G. Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities. Molecules 2012, 17, 1113-1123.
de Oliveira CB, Comunello LN, Lunardelli A, Amaral RH, Pires MGS, da Silva GL, Manfredini V, Vargas CR, Gnoatto SCB, de Oliveira JR, Gosmann G. Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities. Molecules. 2012; 17(1):1113-1123.
de Oliveira, Cristiane B.; Comunello, Lucimara N.; Lunardelli, Adroaldo; Amaral, Robson H.; Pires, Melissa G. S.; da Silva, Gabriela Lucas; Manfredini, Vanusa; Vargas, Carmen Regla; Gnoatto, Simone C. B.; de Oliveira, Jarbas R.; Gosmann, Grace. 2012. "Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities." Molecules 17, no. 1: 1113-1123.