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Molecules 2012, 17(1), 1113-1123; doi:10.3390/molecules17011113
Article

Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities

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1 Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil 2 Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil 3 Hospital de Clínicas de Porto Alegre, Serviço de Genética Médica, UFRGS, Porto Alegre, RS 93050-150, Brazil
* Author to whom correspondence should be addressed.
Received: 5 December 2011 / Revised: 27 December 2011 / Accepted: 9 January 2012 / Published: 23 January 2012
(This article belongs to the Section Natural Products)
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Abstract

Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.
Keywords: anti-inflammatory; antioxidant; Baccharis trimera; phenolic compounds; pleurisy; saponin; TAR anti-inflammatory; antioxidant; Baccharis trimera; phenolic compounds; pleurisy; saponin; TAR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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de Oliveira, C.B.; Comunello, L.N.; Lunardelli, A.; Amaral, R.H.; Pires, M.G.S.; da Silva, G.L.; Manfredini, V.; Vargas, C.R.; Gnoatto, S.C.B.; de Oliveira, J.R.; Gosmann, G. Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities. Molecules 2012, 17, 1113-1123.

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