Next Article in Journal
New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation
Previous Article in Journal
The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(1), 1113-1123; doi:10.3390/molecules17011113

Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities

1
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil
2
Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil
3
Hospital de Clínicas de Porto Alegre, Serviço de Genética Médica, UFRGS, Porto Alegre, RS 93050-150, Brazil
*
Author to whom correspondence should be addressed.
Received: 5 December 2011 / Revised: 27 December 2011 / Accepted: 9 January 2012 / Published: 23 January 2012
(This article belongs to the Section Natural Products)
Download PDF [246 KB, uploaded 18 June 2014]   |  

Abstract

Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.
Keywords: anti-inflammatory; antioxidant; Baccharis trimera; phenolic compounds; pleurisy; saponin; TAR anti-inflammatory; antioxidant; Baccharis trimera; phenolic compounds; pleurisy; saponin; TAR
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

de Oliveira, C.B.; Comunello, L.N.; Lunardelli, A.; Amaral, R.H.; Pires, M.G.S.; da Silva, G.L.; Manfredini, V.; Vargas, C.R.; Gnoatto, S.C.B.; de Oliveira, J.R.; Gosmann, G. Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities. Molecules 2012, 17, 1113-1123.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top