Molecules 2011, 16(9), 7634-7648; doi:10.3390/molecules16097634
Article

A Novel Anti-Inflammatory Role for Ginkgolide B in Asthma via Inhibition of the ERK/MAPK Signaling Pathway

1,†, 1,†, 2,†, 1, 1, 3, 1, 1, 1, 4,* email and 1,* email
Received: 19 July 2011; in revised form: 11 August 2011 / Accepted: 16 August 2011 / Published: 6 September 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Ginkgolide B is an anti-inflammatory extract of Ginkgo biloba and has been used therapeutically. It is a known inhibitor of platelet activating factor (PAF), which is important in the pathogenesis of asthma. Here, a non-infectious mouse model of asthma is used to evaluate the anti-inflammatory capacity of ginkgolide B (GKB) and characterize the interaction of GKB with the mitogen activated protein kinase (MAPK) pathway. BALB/c mice that were sensitized and challenged to ovalbumin (OVA) were treated with GKB (40 mg/kg) one hour before they were challenged with OVA. Our study demonstrated that GKB may effectively inhibit the increase of T-helper 2 cytokines, such as interleukin (IL)-5 and IL-13 in bronchoalveolar lavage fluid (BALF). Furthermore, the eosinophil count in BALF significantly decreased after treatment of GKB when compared with the OVA-challenged group. Histological studies demonstrated that GKB substantially inhibited OVA-induced eosinophilia in lung tissue and mucus hyper-secretion by goblet cells in the airway. These results suggest that ginkgolide B may be useful for the treatment of asthma and its efficacy is related to suppression of extracellular regulating kinase/MAPK pathway.
Keywords: ginkgolide B; MAPK; asthma; airway inflammation; airway hyper-responsiveness
PDF Full-text Download PDF Full-Text [1061 KB, uploaded 18 June 2014 19:40 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Chu, X.; Ci, X.; He, J.; Wei, M.; Yang, X.; Cao, Q.; Li, H.; Guan, S.; Deng, Y.; Pang, D.; Deng, X. A Novel Anti-Inflammatory Role for Ginkgolide B in Asthma via Inhibition of the ERK/MAPK Signaling Pathway. Molecules 2011, 16, 7634-7648.

AMA Style

Chu X, Ci X, He J, Wei M, Yang X, Cao Q, Li H, Guan S, Deng Y, Pang D, Deng X. A Novel Anti-Inflammatory Role for Ginkgolide B in Asthma via Inhibition of the ERK/MAPK Signaling Pathway. Molecules. 2011; 16(9):7634-7648.

Chicago/Turabian Style

Chu, Xiao; Ci, Xinxin; He, Jiakang; Wei, Miaomiao; Yang, Xiaofeng; Cao, Qingjun; Li, Hongyu; Guan, Shuang; Deng, Yanhong; Pang, Daxin; Deng, Xuming. 2011. "A Novel Anti-Inflammatory Role for Ginkgolide B in Asthma via Inhibition of the ERK/MAPK Signaling Pathway." Molecules 16, no. 9: 7634-7648.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert