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Molecules 2011, 16(9), 7634-7648; doi:10.3390/molecules16097634
Article

A Novel Anti-Inflammatory Role for Ginkgolide B in Asthma via Inhibition of the ERK/MAPK Signaling Pathway

1,†, 1,†, 2,†, 1, 1, 3, 1, 1, 1, 4,*  and 1,*
1 Key Laboratory of Zoonosis Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China 2 College of Animal Science and Technology, Guangxi University, 100 Daxue Road, Nanning 530005, Guangxi, China 3 College of Plant Science, Jilin University, Changchun 130062, China 4 Key Laboratory of Animal Embryo Engineering, Department of Animal Biotechnology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 19 July 2011 / Revised: 11 August 2011 / Accepted: 16 August 2011 / Published: 6 September 2011
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Abstract

Ginkgolide B is an anti-inflammatory extract of Ginkgo biloba and has been used therapeutically. It is a known inhibitor of platelet activating factor (PAF), which is important in the pathogenesis of asthma. Here, a non-infectious mouse model of asthma is used to evaluate the anti-inflammatory capacity of ginkgolide B (GKB) and characterize the interaction of GKB with the mitogen activated protein kinase (MAPK) pathway. BALB/c mice that were sensitized and challenged to ovalbumin (OVA) were treated with GKB (40 mg/kg) one hour before they were challenged with OVA. Our study demonstrated that GKB may effectively inhibit the increase of T-helper 2 cytokines, such as interleukin (IL)-5 and IL-13 in bronchoalveolar lavage fluid (BALF). Furthermore, the eosinophil count in BALF significantly decreased after treatment of GKB when compared with the OVA-challenged group. Histological studies demonstrated that GKB substantially inhibited OVA-induced eosinophilia in lung tissue and mucus hyper-secretion by goblet cells in the airway. These results suggest that ginkgolide B may be useful for the treatment of asthma and its efficacy is related to suppression of extracellular regulating kinase/MAPK pathway.
Keywords: ginkgolide B; MAPK; asthma; airway inflammation; airway hyper-responsiveness ginkgolide B; MAPK; asthma; airway inflammation; airway hyper-responsiveness
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chu, X.; Ci, X.; He, J.; Wei, M.; Yang, X.; Cao, Q.; Li, H.; Guan, S.; Deng, Y.; Pang, D.; Deng, X. A Novel Anti-Inflammatory Role for Ginkgolide B in Asthma via Inhibition of the ERK/MAPK Signaling Pathway. Molecules 2011, 16, 7634-7648.

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