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Molecules 2011, 16(9), 7377-7390; doi:10.3390/molecules16097377

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

1
Chemical Engineering & Molecules for Life Sciences Group, Université de Rennes 1, Sciences Chimiques de Rennes (SCR), UMR CNRS 6226, Bât. 10A, Campus de Beaulieu, Avenue du Général Leclerc, CS 74205, 35042 Rennes Cedex, France
2
Protein Phosphorylation and Human Disease Group, Station Biologique CNRS, Place G. Tessier, BP 74, 29682 Roscoff, France
*
Author to whom correspondence should be addressed.
Received: 13 July 2011 / Revised: 25 August 2011 / Accepted: 22 August 2011 / Published: 30 August 2011
(This article belongs to the Section Organic Synthesis)
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Abstract

A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.
Keywords: 1,5-dihydro-4H-imidazol-4one; Knoevenagel condensation; microwave irradiation; S-alkylation 1,5-dihydro-4H-imidazol-4one; Knoevenagel condensation; microwave irradiation; S-alkylation
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bourahla, K.; Paquin, L.; Lozach, O.; Meijer, L.; Carreaux, F.; Bazureau, J.P. A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives. Molecules 2011, 16, 7377-7390.

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