Molecules 2011, 16(9), 7377-7390; doi:10.3390/molecules16097377
Article

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

1, 1, 2, 2, 1 and 1,* email
Received: 13 July 2011; in revised form: 25 August 2011 / Accepted: 22 August 2011 / Published: 30 August 2011
(This article belongs to the Section Organic Synthesis)
Download PDF [456 KB, uploaded 18 June 2014]
Abstract: A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.
Keywords: 1,5-dihydro-4H-imidazol-4one; Knoevenagel condensation; microwave irradiation; S-alkylation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Bourahla, K.; Paquin, L.; Lozach, O.; Meijer, L.; Carreaux, F.; Bazureau, J.P. A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives. Molecules 2011, 16, 7377-7390.

AMA Style

Bourahla K, Paquin L, Lozach O, Meijer L, Carreaux F, Bazureau JP. A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives. Molecules. 2011; 16(9):7377-7390.

Chicago/Turabian Style

Bourahla, Khadidja; Paquin, Ludovic; Lozach, Olivier; Meijer, Laurent; Carreaux, François; Bazureau, Jean Pierre. 2011. "A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives." Molecules 16, no. 9: 7377-7390.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert