Molecules 2011, 16(8), 6732-6740; doi:10.3390/molecules16086732
Review

Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease

Hong-Fang Ji and Liang Shen* email
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
* Author to whom correspondence should be addressed.
Received: 11 July 2011; in revised form: 23 July 2011 / Accepted: 2 August 2011 / Published: 9 August 2011
(This article belongs to the Section Natural Products)
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Abstract: With the accelerated aging of human society Alzheimer’s disease (AD) has become one of the most threatening diseases in the elderly. However, there is no efficient therapeutic agent to combat AD. Berberine is a natural isoquinoline alkaloid that possesses a wide range of pharmacological effects. In the present paper, we review the multiple activities of berberine, including antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitory, monoamine oxidase inhibitory, amyloid-b peptide level-reducing and cholesterol-lowering activities, which suggest that berberine may act as a promising multipotent agent to combat AD.
Keywords: Alzheimer’s disease; berberine; multipotent agent

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Cite This Article

MDPI and ACS Style

Ji, H.-F.; Shen, L. Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease. Molecules 2011, 16, 6732-6740.

AMA Style

Ji H-F, Shen L. Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease. Molecules. 2011; 16(8):6732-6740.

Chicago/Turabian Style

Ji, Hong-Fang; Shen, Liang. 2011. "Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease." Molecules 16, no. 8: 6732-6740.

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