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Molecules 2011, 16(8), 6732-6740; doi:10.3390/molecules16086732

Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease

Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
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Received: 11 July 2011 / Revised: 23 July 2011 / Accepted: 2 August 2011 / Published: 9 August 2011
(This article belongs to the Section Natural Products)
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Abstract

With the accelerated aging of human society Alzheimer’s disease (AD) has become one of the most threatening diseases in the elderly. However, there is no efficient therapeutic agent to combat AD. Berberine is a natural isoquinoline alkaloid that possesses a wide range of pharmacological effects. In the present paper, we review the multiple activities of berberine, including antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitory, monoamine oxidase inhibitory, amyloid-b peptide level-reducing and cholesterol-lowering activities, which suggest that berberine may act as a promising multipotent agent to combat AD.
Keywords: Alzheimer’s disease; berberine; multipotent agent Alzheimer’s disease; berberine; multipotent agent
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ji, H.-F.; Shen, L. Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease. Molecules 2011, 16, 6732-6740.

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