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Molecules 2011, 16(8), 6470-6480; doi:10.3390/molecules16086470
Article

Expeditious Entry to Novel 2-Methylene-2,3-dihydrofuro[3,2-c] chromen-2-ones from 6-Chloro-4-hydroxychromen-2-one and Propargylic Alcohols

, ,  and *
Received: 14 July 2011; in revised form: 27 July 2011 / Accepted: 28 July 2011 / Published: 2 August 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract: A catalytic system consisting of the ruthenium(II) complex [Ru(η3-2-C3H4Me)(CO)(dppf)][SbF6] (dppf = 1,1’-bis(diphenylphosphino)ferrocene) and trifluoroacetic acid has been used to promote the coupling of secondary propargylic alcohols with 6-chloro-4-hydroxychromen-2-one. The reactions afforded unusual 2-methylene-2,3-dihydrofuro[3,2-c]chromen-2-ones in good yields.
Keywords: chromen-2-ones; furochromen-2-ones; propargylic alcohols; ruthenium catalysts; propargylation; cycloisomerization chromen-2-ones; furochromen-2-ones; propargylic alcohols; ruthenium catalysts; propargylation; cycloisomerization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nebra, N.; Díaz-Álvarez, A.E.; Díez, J.; Cadierno, V. Expeditious Entry to Novel 2-Methylene-2,3-dihydrofuro[3,2-c] chromen-2-ones from 6-Chloro-4-hydroxychromen-2-one and Propargylic Alcohols. Molecules 2011, 16, 6470-6480.

AMA Style

Nebra N, Díaz-Álvarez AE, Díez J, Cadierno V. Expeditious Entry to Novel 2-Methylene-2,3-dihydrofuro[3,2-c] chromen-2-ones from 6-Chloro-4-hydroxychromen-2-one and Propargylic Alcohols. Molecules. 2011; 16(8):6470-6480.

Chicago/Turabian Style

Nebra, Noel; Díaz-Álvarez, Alba E.; Díez, Josefina; Cadierno, Victorio. 2011. "Expeditious Entry to Novel 2-Methylene-2,3-dihydrofuro[3,2-c] chromen-2-ones from 6-Chloro-4-hydroxychromen-2-one and Propargylic Alcohols." Molecules 16, no. 8: 6470-6480.


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