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Molecules 2011, 16(8), 6470-6480; doi:10.3390/molecules16086470

Expeditious Entry to Novel 2-Methylene-2,3-dihydrofuro[3,2-c] chromen-2-ones from 6-Chloro-4-hydroxychromen-2-one and Propargylic Alcohols

Departamento de Química Orgánica e Inorgánica, IUQOEM-CSIC, Facultad de Química, Universidad de Oviedo, E-33071 Oviedo, Spain
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Received: 14 July 2011 / Revised: 27 July 2011 / Accepted: 28 July 2011 / Published: 2 August 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

A catalytic system consisting of the ruthenium(II) complex [Ru(η3-2-C3H4Me)(CO)(dppf)][SbF6] (dppf = 1,1’-bis(diphenylphosphino)ferrocene) and trifluoroacetic acid has been used to promote the coupling of secondary propargylic alcohols with 6-chloro-4-hydroxychromen-2-one. The reactions afforded unusual 2-methylene-2,3-dihydrofuro[3,2-c]chromen-2-ones in good yields.
Keywords: chromen-2-ones; furochromen-2-ones; propargylic alcohols; ruthenium catalysts; propargylation; cycloisomerization chromen-2-ones; furochromen-2-ones; propargylic alcohols; ruthenium catalysts; propargylation; cycloisomerization
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MDPI and ACS Style

Nebra, N.; Díaz-Álvarez, A.E.; Díez, J.; Cadierno, V. Expeditious Entry to Novel 2-Methylene-2,3-dihydrofuro[3,2-c] chromen-2-ones from 6-Chloro-4-hydroxychromen-2-one and Propargylic Alcohols. Molecules 2011, 16, 6470-6480.

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