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Molecules 2011, 16(8), 6502-6511; doi:10.3390/molecules16086502
Article

1,1’-(3-Methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone as a Building Block in Heterocyclic Synthesis. Novel Synthesis of Some Pyrazole and Pyrimidine Derivatives

1,* , 1, 1,* , 1 and 2
Received: 20 June 2011 / Revised: 25 July 2011 / Accepted: 29 July 2011 / Published: 3 August 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

A series of new bis(heterocycles) featuring thieno[2,3-b]thiophene rings was synthesized in a combinatorial manner. Intramolecular cyclization of enaminone derivatives with appropriate N-nucleophiles afforded the target compounds. All compounds were characterized by 1H-, 13C-NMR, GCMS, IR, and UV-Vis spectrometry. These compounds represent a new class of sulfur- and nitrogen-containing heterocycles that should also be of interest as new materials.
Keywords: thienothiophene; enaminones; bis-heterocycles; intramolecular cyclization; DMF-DMA thienothiophene; enaminones; bis-heterocycles; intramolecular cyclization; DMF-DMA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mabkhot, Y.N.; Al-Majid, A.M.; Barakat, A.; Alshahrani, S.; Siddiqui, Y. 1,1’-(3-Methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone as a Building Block in Heterocyclic Synthesis. Novel Synthesis of Some Pyrazole and Pyrimidine Derivatives. Molecules 2011, 16, 6502-6511.

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