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Molecules 2011, 16(8), 6502-6511; doi:10.3390/molecules16086502
Article

1,1’-(3-Methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone as a Building Block in Heterocyclic Synthesis. Novel Synthesis of Some Pyrazole and Pyrimidine Derivatives

1,* , 1, 1,* , 1 and 2
1 Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia 2 Department of Chemistry, Faculty of Science, Taibah University, P.O. Box 344, Medina 41411, Saudi Arabia
* Authors to whom correspondence should be addressed.
Received: 20 June 2011 / Revised: 25 July 2011 / Accepted: 29 July 2011 / Published: 3 August 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

A series of new bis(heterocycles) featuring thieno[2,3-b]thiophene rings was synthesized in a combinatorial manner. Intramolecular cyclization of enaminone derivatives with appropriate N-nucleophiles afforded the target compounds. All compounds were characterized by 1H-, 13C-NMR, GCMS, IR, and UV-Vis spectrometry. These compounds represent a new class of sulfur- and nitrogen-containing heterocycles that should also be of interest as new materials.
Keywords: thienothiophene; enaminones; bis-heterocycles; intramolecular cyclization; DMF-DMA thienothiophene; enaminones; bis-heterocycles; intramolecular cyclization; DMF-DMA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Mabkhot, Y.N.; Al-Majid, A.M.; Barakat, A.; Alshahrani, S.; Siddiqui, Y. 1,1’-(3-Methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone as a Building Block in Heterocyclic Synthesis. Novel Synthesis of Some Pyrazole and Pyrimidine Derivatives. Molecules 2011, 16, 6502-6511.

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