Molecules 2011, 16(8), 6339-6348; doi:10.3390/molecules16086339
Article

Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation

Dong-Ping Liu 1,† email, Qiang Luo 1,† email, Guang-Hui Wang 1 email, Yang Xu 1 email, Xiao-Kun Zhang 1,2 email, Quan-Cheng Chen 1,* email and Hai-Feng Chen 1,* email
1 School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China 2 Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA † These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 12 May 2011; in revised form: 5 July 2011 / Accepted: 14 July 2011 / Published: 26 July 2011
(This article belongs to the Section Natural Products)
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Abstract: A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2–18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by analysis of IR, NMR, and HR-ESI-MS spectroscopic data. Among the isolated compounds, 13, 16, and 18 (each at 20 μM) could significantly promote the gene transcriptional function of nuclear receptor RXRα. While 7–9, 13, 14, and the new structure 1 (each at 20 μM) showed significant reduction in RXRα gene transcriptional activities induced by 9-cis-retinoid acid. The findings indicated that these furocoumarin skeleton derivatives might hold beneficial effects on many intractable diseases, such as cancer and metabolic diseases, due to their potential activities on regulating the transcriptional activation function of RXRα.
Keywords: Radix Angelicae Dahuricae; furocoumarins; nuclear receptor RXRα

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Cite This Article

MDPI and ACS Style

Liu, D.-P.; Luo, Q.; Wang, G.-H.; Xu, Y.; Zhang, X.-K.; Chen, Q.-C.; Chen, H.-F. Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation. Molecules 2011, 16, 6339-6348.

AMA Style

Liu D-P, Luo Q, Wang G-H, Xu Y, Zhang X-K, Chen Q-C, Chen H-F. Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation. Molecules. 2011; 16(8):6339-6348.

Chicago/Turabian Style

Liu, Dong-Ping; Luo, Qiang; Wang, Guang-Hui; Xu, Yang; Zhang, Xiao-Kun; Chen, Quan-Cheng; Chen, Hai-Feng. 2011. "Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation." Molecules 16, no. 8: 6339-6348.

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