Next Article in Journal
Novel Library of Selenocompounds as Kinase Modulators
Previous Article in Journal
Rhinacanthus nasutus Protects Cultured Neuronal Cells against Hypoxia Induced Cell Death
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(8), 6339-6348; doi:10.3390/molecules16086339

Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation

School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China
Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 12 May 2011 / Revised: 5 July 2011 / Accepted: 14 July 2011 / Published: 26 July 2011
(This article belongs to the Section Natural Products)
Download PDF [482 KB, uploaded 18 June 2014]


A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2–18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by analysis of IR, NMR, and HR-ESI-MS spectroscopic data. Among the isolated compounds, 13, 16, and 18 (each at 20 μM) could significantly promote the gene transcriptional function of nuclear receptor RXRα. While 79, 13, 14, and the new structure 1 (each at 20 μM) showed significant reduction in RXRα gene transcriptional activities induced by 9-cis-retinoid acid. The findings indicated that these furocoumarin skeleton derivatives might hold beneficial effects on many intractable diseases, such as cancer and metabolic diseases, due to their potential activities on regulating the transcriptional activation function of RXRα.
Keywords: Radix Angelicae Dahuricae; furocoumarins; nuclear receptor RXRα Radix Angelicae Dahuricae; furocoumarins; nuclear receptor RXRα
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liu, D.-P.; Luo, Q.; Wang, G.-H.; Xu, Y.; Zhang, X.-K.; Chen, Q.-C.; Chen, H.-F. Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation. Molecules 2011, 16, 6339-6348.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top