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Molecules 2011, 16(7), 5453-5459; doi:10.3390/molecules16075453
Article

In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains

1,* , 1,2
,
3
,
2,* , 1, 1
 and
1
1 Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China 2 School of Pharmacy, Guiyang Medical College, Guiyang 550004, China 3 School of Basic Medicine, Yunnan Traditional Chinese Medical College, Kunming 650500, China
* Authors to whom correspondence should be addressed.
Received: 23 May 2011 / Revised: 12 June 2011 / Accepted: 13 June 2011 / Published: 28 June 2011
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Abstract

The antibacterial activity of 80% ethanol extracts of 10 medicinal plants collected in Yunnan (Southwest China), was tested against clinical isolates of extended-spectrum b-lactamase (ESBL)-producing strains. Their MIC values ranged between 1.56–12.50 mg/mL. The most active plant extract was Chelidonium majus L. (MIC = 1.56 mg/mL). Two potent isoquinoline alkaloids, 8-hydroxydihydrosanguinarine and 8-hydroxydihydrochelerythrine, were identified as the major active principles through bioassay-guided fractionation and identification of the active ethyl acetate fraction from C. majus, with minimum MIC/MBC values of 15.63/62.50 mg/mL.
Keywords: antibacterial plant extracts; ESBLs; 8-hydroxydihydrosanguinarine; 8-hydroxydihydrochelerythrine antibacterial plant extracts; ESBLs; 8-hydroxydihydrosanguinarine; 8-hydroxydihydrochelerythrine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zuo, G.-Y.; Meng, F.-Y.; Han, J.; Hao, X.-Y.; Wang, G.-C.; Zhang, Y.-L.; Zhang, Q. In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains. Molecules 2011, 16, 5453-5459.

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