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Molecules 2011, 16(7), 5453-5459; doi:10.3390/molecules16075453
Article

In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains

1,* , 1,2
, 3
, 2,* , 1, 1
 and 1
1 Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China 2 School of Pharmacy, Guiyang Medical College, Guiyang 550004, China 3 School of Basic Medicine, Yunnan Traditional Chinese Medical College, Kunming 650500, China
* Authors to whom correspondence should be addressed.
Received: 23 May 2011 / Revised: 12 June 2011 / Accepted: 13 June 2011 / Published: 28 June 2011
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Abstract

The antibacterial activity of 80% ethanol extracts of 10 medicinal plants collected in Yunnan (Southwest China), was tested against clinical isolates of extended-spectrum b-lactamase (ESBL)-producing strains. Their MIC values ranged between 1.56–12.50 mg/mL. The most active plant extract was Chelidonium majus L. (MIC = 1.56 mg/mL). Two potent isoquinoline alkaloids, 8-hydroxydihydrosanguinarine and 8-hydroxydihydrochelerythrine, were identified as the major active principles through bioassay-guided fractionation and identification of the active ethyl acetate fraction from C. majus, with minimum MIC/MBC values of 15.63/62.50 mg/mL.
Keywords: antibacterial plant extracts; ESBLs; 8-hydroxydihydrosanguinarine; 8-hydroxydihydrochelerythrine antibacterial plant extracts; ESBLs; 8-hydroxydihydrosanguinarine; 8-hydroxydihydrochelerythrine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zuo, G.-Y.; Meng, F.-Y.; Han, J.; Hao, X.-Y.; Wang, G.-C.; Zhang, Y.-L.; Zhang, Q. In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains. Molecules 2011, 16, 5453-5459.

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