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Molecules 2011, 16(7), 5453-5459; doi:10.3390/molecules16075453
Article

In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains

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Received: 23 May 2011; in revised form: 12 June 2011 / Accepted: 13 June 2011 / Published: 28 June 2011
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Abstract: The antibacterial activity of 80% ethanol extracts of 10 medicinal plants collected in Yunnan (Southwest China), was tested against clinical isolates of extended-spectrum b-lactamase (ESBL)-producing strains. Their MIC values ranged between 1.56–12.50 mg/mL. The most active plant extract was Chelidonium majus L. (MIC = 1.56 mg/mL). Two potent isoquinoline alkaloids, 8-hydroxydihydrosanguinarine and 8-hydroxydihydrochelerythrine, were identified as the major active principles through bioassay-guided fractionation and identification of the active ethyl acetate fraction from C. majus, with minimum MIC/MBC values of 15.63/62.50 mg/mL.
Keywords: antibacterial plant extracts; ESBLs; 8-hydroxydihydrosanguinarine; 8-hydroxydihydrochelerythrine antibacterial plant extracts; ESBLs; 8-hydroxydihydrosanguinarine; 8-hydroxydihydrochelerythrine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zuo, G.-Y.; Meng, F.-Y.; Han, J.; Hao, X.-Y.; Wang, G.-C.; Zhang, Y.-L.; Zhang, Q. In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains. Molecules 2011, 16, 5453-5459.

AMA Style

Zuo G-Y, Meng F-Y, Han J, Hao X-Y, Wang G-C, Zhang Y-L, Zhang Q. In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains. Molecules. 2011; 16(7):5453-5459.

Chicago/Turabian Style

Zuo, Guo-Ying; Meng, Fan-Yan; Han, Jun; Hao, Xiao-Yan; Wang, Gen-Chun; Zhang, Yun-Ling; Zhang, Qing. 2011. "In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains." Molecules 16, no. 7: 5453-5459.


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