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Molecules 2011, 16(7), 5437-5452; doi:10.3390/molecules16075437
Review

Recent Developments in Molecular Dynamics Simulations of Fluorescent Membrane Probes

1,2
 and 3,*
Received: 29 March 2011; in revised form: 21 June 2011 / Accepted: 22 June 2011 / Published: 27 June 2011
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Abstract: Due to their sensitivity and versatility, the use of fluorescence techniques in membrane biophysics is widespread. Because membrane lipids are non-fluorescent, extrinsic membrane probes are widely used. However, the behaviour of these probes when inserted in the bilayer is often poorly understood, and it can be hard to distinguish between legitimate membrane properties and perturbation resulting from probe incorporation. Atomistic molecular dynamics simulations present a convenient way to address these issues and have been increasingly used in recent years in this context. This article reviews the application of molecular dynamics to the study of fluorescent membrane probes, focusing on recent work with complex design fluorophores and ordered bilayer systems.
Keywords: fluorescence; lipid bilayer; molecular dynamics; molecular simulation; membrane probes fluorescence; lipid bilayer; molecular dynamics; molecular simulation; membrane probes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Loura, L.M.S.; Ramalho, J.P.P. Recent Developments in Molecular Dynamics Simulations of Fluorescent Membrane Probes. Molecules 2011, 16, 5437-5452.

AMA Style

Loura LMS, Ramalho JPP. Recent Developments in Molecular Dynamics Simulations of Fluorescent Membrane Probes. Molecules. 2011; 16(7):5437-5452.

Chicago/Turabian Style

Loura, Luís M. S.; Ramalho, J. P. Prates. 2011. "Recent Developments in Molecular Dynamics Simulations of Fluorescent Membrane Probes." Molecules 16, no. 7: 5437-5452.


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