Next Article in Journal
In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains
Next Article in Special Issue
Li+ Selective Podand-Type Fluoroionophore Based on a Diphenyl Sulfoxide Derivative Bearing Two Pyrene Groups
Previous Article in Journal
Synthesis of Key Fragments of Amphidinolide Q — A Cytotoxic 12-membered Macrolide
Previous Article in Special Issue
Fluorescent Probes Detecting the Phagocytic Phase of Apoptosis: Enzyme-Substrate Complexes of Topoisomerase and DNA
Article Menu

Article Versions

Export Article

Open AccessReview
Molecules 2011, 16(7), 5437-5452; doi:10.3390/molecules16075437

Recent Developments in Molecular Dynamics Simulations of Fluorescent Membrane Probes

Faculdade de Farmácia, Universidade de Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
Centro de Química de Coimbra, Universidade de Coimbra, Rua Larga, 3004-535 Coimbra, Portugal
Centro de Química de Évora e Departamento de Química, Escola de Ciências e Tecnologia, Colégio Luís Verney, Rua Romão Ramalho 59, 7002-554 Évora, Portugal
Author to whom correspondence should be addressed.
Received: 29 March 2011 / Revised: 21 June 2011 / Accepted: 22 June 2011 / Published: 27 June 2011
Download PDF [751 KB, uploaded 18 June 2014]   |  


Due to their sensitivity and versatility, the use of fluorescence techniques in membrane biophysics is widespread. Because membrane lipids are non-fluorescent, extrinsic membrane probes are widely used. However, the behaviour of these probes when inserted in the bilayer is often poorly understood, and it can be hard to distinguish between legitimate membrane properties and perturbation resulting from probe incorporation. Atomistic molecular dynamics simulations present a convenient way to address these issues and have been increasingly used in recent years in this context. This article reviews the application of molecular dynamics to the study of fluorescent membrane probes, focusing on recent work with complex design fluorophores and ordered bilayer systems.
Keywords: fluorescence; lipid bilayer; molecular dynamics; molecular simulation; membrane probes fluorescence; lipid bilayer; molecular dynamics; molecular simulation; membrane probes

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Loura, L.M.S.; Ramalho, J.P.P. Recent Developments in Molecular Dynamics Simulations of Fluorescent Membrane Probes. Molecules 2011, 16, 5437-5452.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top