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Molecules 2011, 16(6), 5283-5297; doi:10.3390/molecules16065283
Review

The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine

1, 1,2 and 1,*
Received: 18 April 2011; in revised form: 17 June 2011 / Accepted: 20 June 2011 / Published: 23 June 2011
(This article belongs to the collection Bioactive Compounds)
Download PDF [341 KB, updated 18 June 2014; original version uploaded 18 June 2014]
Abstract: The thunder god vine or Tripterygium wilfordii Hook. F. is a representative Chinese medicinal herb which has been used widely and successfully for centuries in treating inflammatory diseases. More than 100 components have been isolated from this plant, and most of them have potent therapeutic efficacy for a variety of autoimmune and inflammatory diseases. In the past four decades, the anticancer activities of the extracts from this medicinal herb have attracted intensive attention by researchers worldwide. The diterpenoid epoxide triptolide and the quinone triterpene celastrol are two important bioactive ingredients that show a divergent therapeutic profile and can perturb multiple signal pathways. Both compounds promise to turn traditional medicines into modern drugs. In this review, we will mainly address the anticancer activities and mechanisms of action of these two agents and briefly describe some other antitumor components of the thunder god vine.
Keywords: Thunder god vine/Tripterygium wilfordii Hook. f.; triptolide; celastrol; anticancer activity Thunder god vine/Tripterygium wilfordii Hook. f.; triptolide; celastrol; anticancer activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liu, Z.; Ma, L.; Zhou, G.-B. The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine. Molecules 2011, 16, 5283-5297.

AMA Style

Liu Z, Ma L, Zhou G-B. The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine. Molecules. 2011; 16(6):5283-5297.

Chicago/Turabian Style

Liu, Zi; Ma, Liang; Zhou, Guang-Biao. 2011. "The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine." Molecules 16, no. 6: 5283-5297.



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