Next Article in Journal
Enantio and Diastereoselective Addition of Phenylacetylene to Racemic α-chloroketones
Next Article in Special Issue
Absorbable Phenylpropenoyl Sucroses from Polygala tenuifolia
Previous Article in Journal
Acute Oral Toxicity of Methanolic Seed Extract of Cassia fistula in Mice
Previous Article in Special Issue
Biomolecule Profiles in Inedible Wild Mushrooms with Antioxidant Value
Molecules 2011, 16(6), 5283-5297; doi:10.3390/molecules16065283
Review

The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine

1, 1,2 and 1,*
Received: 18 April 2011 / Revised: 17 June 2011 / Accepted: 20 June 2011 / Published: 23 June 2011
(This article belongs to the collection Bioactive Compounds)
Download PDF [341 KB, 18 June 2014; original version 18 June 2014]

Abstract

The thunder god vine or Tripterygium wilfordii Hook. F. is a representative Chinese medicinal herb which has been used widely and successfully for centuries in treating inflammatory diseases. More than 100 components have been isolated from this plant, and most of them have potent therapeutic efficacy for a variety of autoimmune and inflammatory diseases. In the past four decades, the anticancer activities of the extracts from this medicinal herb have attracted intensive attention by researchers worldwide. The diterpenoid epoxide triptolide and the quinone triterpene celastrol are two important bioactive ingredients that show a divergent therapeutic profile and can perturb multiple signal pathways. Both compounds promise to turn traditional medicines into modern drugs. In this review, we will mainly address the anticancer activities and mechanisms of action of these two agents and briefly describe some other antitumor components of the thunder god vine.
Keywords: Thunder god vine/Tripterygium wilfordii Hook. f.; triptolide; celastrol; anticancer activity Thunder god vine/Tripterygium wilfordii Hook. f.; triptolide; celastrol; anticancer activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Liu, Z.; Ma, L.; Zhou, G.-B. The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine. Molecules 2011, 16, 5283-5297.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert