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The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine
Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
* Author to whom correspondence should be addressed.
Received: 18 April 2011; in revised form: 17 June 2011 / Accepted: 20 June 2011 / Published: 23 June 2011
Abstract: The thunder god vine or Tripterygium wilfordii Hook. F. is a representative Chinese medicinal herb which has been used widely and successfully for centuries in treating inflammatory diseases. More than 100 components have been isolated from this plant, and most of them have potent therapeutic efficacy for a variety of autoimmune and inflammatory diseases. In the past four decades, the anticancer activities of the extracts from this medicinal herb have attracted intensive attention by researchers worldwide. The diterpenoid epoxide triptolide and the quinone triterpene celastrol are two important bioactive ingredients that show a divergent therapeutic profile and can perturb multiple signal pathways. Both compounds promise to turn traditional medicines into modern drugs. In this review, we will mainly address the anticancer activities and mechanisms of action of these two agents and briefly describe some other antitumor components of the thunder god vine.
Keywords: Thunder god vine/Tripterygium wilfordii Hook. f.; triptolide; celastrol; anticancer activity
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MDPI and ACS Style
Liu, Z.; Ma, L.; Zhou, G.-B. The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine. Molecules 2011, 16, 5283-5297.
Liu Z, Ma L, Zhou G-B. The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine. Molecules. 2011; 16(6):5283-5297.
Liu, Zi; Ma, Liang; Zhou, Guang-Biao. 2011. "The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine." Molecules 16, no. 6: 5283-5297.