Next Article in Journal
The Immuno-Regulatory Effects of Schisandra chinensis and Its Constituents on Human Monocytic Leukemia Cells
Previous Article in Journal
Effects of Fractionation and Combinatorial Evaluation of Tamarindus indica Fractions for Antibacterial Activity
Molecules 2011, 16(6), 4828-4835; doi:10.3390/molecules16064828
Article

Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance

1,2,* , 3
,
4
,
4
,
1
,
1
,
1
,
3
 and
1,*
Received: 12 May 2011 / Revised: 2 June 2011 / Accepted: 7 June 2011 / Published: 10 June 2011
Download PDF [250 KB, uploaded 18 June 2014]

Abstract

Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones: Apigenine, genkwanine, 7,4’-dimethylapigenin, trimethylapigenin,cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and are recognized as one of the main causes of bacterial drug resistance, since they expel antibiotics from the cell. The inhibition of this transporter is one form of modulating bacterial resistance to antimicrobial drugs. The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance. This property might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups, since 4’,5,6,7 tetramethoxyflavone the most methoxylated compound, reduced the minimal inhibitory concentration of the drug 16-fold.
Keywords: Praxelis clematidea; Asteraceae; flavonoids; antibacterial activity; bacterial resistance; efflux pump Praxelis clematidea; Asteraceae; flavonoids; antibacterial activity; bacterial resistance; efflux pump
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Maia, G.L.A.; Falcão-Silva, V.S.; Aquino, P.G.V.; Araújo-Júnior, J.X.; Tavares, J.F.; Silva, M.S.; Rodrigues, L.C.; Siqueira-Júnior, J.P.; Barbosa-Filho, J.M. Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance. Molecules 2011, 16, 4828-4835.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert