Abstract: Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones: Apigenine, genkwanine, 7,4’-dimethylapigenin, trimethylapigenin,cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and are recognized as one of the main causes of bacterial drug resistance, since they expel antibiotics from the cell. The inhibition of this transporter is one form of modulating bacterial resistance to antimicrobial drugs. The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance. This property might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups, since 4’,5,6,7 tetramethoxyflavone the most methoxylated compound, reduced the minimal inhibitory concentration of the drug 16-fold.
Keywords: Praxelis clematidea; Asteraceae; flavonoids; antibacterial activity; bacterial resistance; efflux pump
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Maia, G.L.A.; Falcão-Silva, V.S.; Aquino, P.G.V.; Araújo-Júnior, J.X.; Tavares, J.F.; Silva, M.S.; Rodrigues, L.C.; Siqueira-Júnior, J.P.; Barbosa-Filho, J.M. Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance. Molecules 2011, 16, 4828-4835.
Maia GLA, Falcão-Silva VS, Aquino PGV, Araújo-Júnior JX, Tavares JF, Silva MS, Rodrigues LC, Siqueira-Júnior JP, Barbosa-Filho JM. Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance. Molecules. 2011; 16(6):4828-4835.
Maia, Gabriela Lemos de Azevedo; Falcão-Silva, Vivyanne dos Santos; Aquino, Pedro Gregório Vieira; Araújo-Júnior, João Xavier de; Tavares, Josean Fechine; Silva, Marcelo Sobral da; Rodrigues, Luis Cezar; Siqueira-Júnior, José Pinto de; Barbosa-Filho, José Maria. 2011. "Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance." Molecules 16, no. 6: 4828-4835.