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Molecules 2011, 16(5), 3778-3786; doi:10.3390/molecules16053778

Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines

Laboratory of Chemical Synthesis and Pollution Control, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637009, Sichuan, China
Author to whom correspondence should be addressed.
Received: 14 March 2011 / Revised: 16 April 2011 / Accepted: 20 April 2011 / Published: 4 May 2011
Download PDF [221 KB, 18 June 2014; original version 18 June 2014]


Highly efficient asymmetric aldol reactions between α,β-unsaturated keto esters and acyclic ketones catalyzed by chiral diamines are reported. The corresponding products were obtained in excellent yields with excellent enantioselectivities. The absolute configuration for the product was determined by X-ray analysis. A variety of substrates were tolerable in the present catalytic system.
Keywords: chiral diamine; enantioselectivity; aldol reaction; configuration chiral diamine; enantioselectivity; aldol reaction; configuration
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kan, S.-S.; Li, J.-Z.; Ni, C.-Y.; Liu, Q.-Z.; Kang, T.-R. Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines. Molecules 2011, 16, 3778-3786.

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