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Molecules 2011, 16(5), 3778-3786; doi:10.3390/molecules16053778
Article

Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines

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Received: 14 March 2011 / Revised: 16 April 2011 / Accepted: 20 April 2011 / Published: 4 May 2011
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Abstract

Highly efficient asymmetric aldol reactions between α,β-unsaturated keto esters and acyclic ketones catalyzed by chiral diamines are reported. The corresponding products were obtained in excellent yields with excellent enantioselectivities. The absolute configuration for the product was determined by X-ray analysis. A variety of substrates were tolerable in the present catalytic system.
Keywords: chiral diamine; enantioselectivity; aldol reaction; configuration chiral diamine; enantioselectivity; aldol reaction; configuration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kan, S.-S.; Li, J.-Z.; Ni, C.-Y.; Liu, Q.-Z.; Kang, T.-R. Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines. Molecules 2011, 16, 3778-3786.

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