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Molecules 2011, 16(5), 3701-3712; doi:10.3390/molecules16053701

Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages

1 Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland 2 Department of Conservative Dentistry and Endodontics Division of Dental Propedeutics, Medical University of Silesia in Katowice, Plac Akademicki 17, 41-902 Bytom, Poland
* Author to whom correspondence should be addressed.
Received: 9 March 2011 / Revised: 27 April 2011 / Accepted: 29 April 2011 / Published: 3 May 2011
(This article belongs to the collection Bioactive Compounds)
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Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ– or PMA– stimulated RAW264.7 macrophages.
Keywords: neobavaisoflavone; anti-inflammatory activity; RAW264.7 macrophages neobavaisoflavone; anti-inflammatory activity; RAW264.7 macrophages
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Szliszka, E.; Skaba, D.; Czuba, Z.P.; Krol, W. Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages. Molecules 2011, 16, 3701-3712.

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