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Molecules 2011, 16(5), 3701-3712; doi:10.3390/molecules16053701
Article

Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages

1
, 2
, 1
 and 1,*
Received: 9 March 2011; in revised form: 27 April 2011 / Accepted: 29 April 2011 / Published: 3 May 2011
(This article belongs to the collection Bioactive Compounds)
Download PDF [229 KB, uploaded 18 June 2014]
Abstract: Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ– or PMA– stimulated RAW264.7 macrophages.
Keywords: neobavaisoflavone; anti-inflammatory activity; RAW264.7 macrophages neobavaisoflavone; anti-inflammatory activity; RAW264.7 macrophages
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Szliszka, E.; Skaba, D.; Czuba, Z.P.; Krol, W. Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages. Molecules 2011, 16, 3701-3712.

AMA Style

Szliszka E, Skaba D, Czuba ZP, Krol W. Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages. Molecules. 2011; 16(5):3701-3712.

Chicago/Turabian Style

Szliszka, Ewelina; Skaba, Dariusz; Czuba, Zenon P.; Krol, Wojciech. 2011. "Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages." Molecules 16, no. 5: 3701-3712.


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