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Molecules 2011, 16(5), 3544-3551; doi:10.3390/molecules16053544
Article

Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids

1,* , 1, 1, 1, 1, 1 and 2
1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 2 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
* Author to whom correspondence should be addressed.
Received: 21 February 2011 / Revised: 30 March 2011 / Accepted: 2 April 2011 / Published: 28 April 2011
(This article belongs to the Section Organic Synthesis)
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Abstract

A facile and efficient method for synthesis of fenamic acid hydrazides from their acids in one-step reaction under microwave irradiation and solvent-free conditions was developed. Compared with the two-step conventional heating method, the process was simple, the reaction time was very short and the yields were almost quantitative.
Keywords: fenamic acids; fenamic acid hydrazides; microwave irradiation; solvent-free reaction fenamic acids; fenamic acid hydrazides; microwave irradiation; solvent-free reaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Aboul-Fadl, T.; Abdel-Aziz, H.A.; Kadi, A.; Bari, A.; Ahmad, P.; Al-Samani, T.; Ng, S.W. Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids. Molecules 2011, 16, 3544-3551.

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