Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids
Abstract
:1. Introduction
2. Results and Discussion
Comp. | Conventional synthesis | MW-assisted synthesis | ||
---|---|---|---|---|
Time of 2 step route (h) | Overall yield (%) | Time (min) | Yield (%) | |
3a | 15 | 80 | 4 | 96 |
3b | 28 | 64 | 12 | 82 |
3c | 17 | 86 | 5 | 85 |
3. Conclusions
4. Experimental
4.1. General
4.2. Conventional Synthesis of Fenamic Acid Hydrazides 3a-c
4.2.1. Step 1
4.2.2. Step 2
4.3. Microwave Irradiation Synthesis of Fenamic Acid Hydrazides 3a-c
4.3.1. 2-(3-(Trifluoromethyl)phenylamino)benzohydrazide (3a)
4.3.2. 2-(2,3-Dimethylphenylamino)benzohydrazide (3b)
4.3.3. 2-(2,6-Dichloro-3-methylphenylamino)benzohydrazide (3c)
Acknowledgements
References and Notes
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- Sample Availability: Samples of the compounds 2a-c and 3a-c are available from Tarek Aboul-Fadl, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
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Aboul-Fadl, T.; Abdel-Aziz, H.A.; Kadi, A.; Bari, A.; Ahmad, P.; Al-Samani, T.; Ng, S.W. Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids. Molecules 2011, 16, 3544-3551. https://doi.org/10.3390/molecules16053544
Aboul-Fadl T, Abdel-Aziz HA, Kadi A, Bari A, Ahmad P, Al-Samani T, Ng SW. Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids. Molecules. 2011; 16(5):3544-3551. https://doi.org/10.3390/molecules16053544
Chicago/Turabian StyleAboul-Fadl, Tarek, Hatem A. Abdel-Aziz, Adnan Kadi, Ahmed Bari, Pervez Ahmad, Tilal Al-Samani, and Seik Weng Ng. 2011. "Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids" Molecules 16, no. 5: 3544-3551. https://doi.org/10.3390/molecules16053544