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Article

Effect of Lectins from Diocleinae Subtribe against Oral Streptococci

by
Theodora Thays Arruda Cavalcante
1,
Bruno Anderson Matias da Rocha
1,
Victor Alves Carneiro
1,
Francisco Vassiliepe Sousa Arruda
2,
Antônia Sâmia Fernandes do Nascimento
1,
Nairley Cardoso Sá
3,
Kyria Santiago Do Nascimento
1,
Benildo Sousa Cavada
1 and
Edson Holanda Teixeira
3,*
1
Department of Biochemistry and Molecular Biology, Faculty of Medicine of Sobral, Federal University of Ceará, Fortaleza, CE, Brazil
2
Northeast Biotechnology Network (RENORBIO), State University of Ceará, 60740-000, Fortaleza, CE, Brazil
3
LIBS, Integrate biomolecules Laboratory, Faculty of Medicine of Sobral, Federal University of Ceará, Sobral, CE, Brazil
*
Author to whom correspondence should be addressed.
Molecules 2011, 16(5), 3530-3543; https://doi.org/10.3390/molecules16053530
Submission received: 30 March 2011 / Revised: 20 April 2011 / Accepted: 25 April 2011 / Published: 27 April 2011
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Surface colonization is an essential step in biofilm development. The ability of oral pathogens to adhere to tooth surfaces is directly linked with the presence of specific molecules at the bacterial surface that can interact with enamel acquired pellicle ligands. In light of this, the aim of this study was to verify inhibitory and antibiofilm action of lectins from the Diocleinaesubtribe against Streptococcus mutans and Streptococcus oralis. The inhibitory action against planctonic cells was assessed using lectins from Canavaliaensi formis (ConA), Canavalia brasiliensis (ConBr), Canavalia maritima (ConM), Canavalia gladiata (CGL) and Canavalia boliviana (ConBol). ConBol, ConBr and ConM showed inhibitory activity on S. mutans growth. All lectins, except ConA, stimulated significantly the growth of S. oralis. To evaluate the effect on biofilm formation, clarified saliva was added to 96-well, flat-bottomed polystyrene plates, followed by the addition of solutions containing 100 or 200 µg/mL of the selected lectins. ConBol, ConM and ConA inhibited the S. mutans biofilms. No effects were found on S. oralis biofilms. Structure/function analysis were carried out using bioinformatics tools. The aperture and deepness of the CRD (Carbohydrate Recognition Domain) permit us to distinguish the two groups of Canavalia lectins in accordance to their actions against S. mutans and S. oralis. The results found provide a basis for encouraging the use of plant lectins as biotechnological tools in ecological control and prevention of caries disease.
Keywords: plant lectins; oral Streptococcus; biofilm plant lectins; oral Streptococcus; biofilm

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MDPI and ACS Style

Cavalcante, T.T.A.; Anderson Matias da Rocha, B.; Alves Carneiro, V.; Vassiliepe Sousa Arruda, F.; Fernandes do Nascimento, A.S.; Cardoso Sá, N.; Do Nascimento, K.S.; Sousa Cavada, B.; Holanda Teixeira, E. Effect of Lectins from Diocleinae Subtribe against Oral Streptococci. Molecules 2011, 16, 3530-3543. https://doi.org/10.3390/molecules16053530

AMA Style

Cavalcante TTA, Anderson Matias da Rocha B, Alves Carneiro V, Vassiliepe Sousa Arruda F, Fernandes do Nascimento AS, Cardoso Sá N, Do Nascimento KS, Sousa Cavada B, Holanda Teixeira E. Effect of Lectins from Diocleinae Subtribe against Oral Streptococci. Molecules. 2011; 16(5):3530-3543. https://doi.org/10.3390/molecules16053530

Chicago/Turabian Style

Cavalcante, Theodora Thays Arruda, Bruno Anderson Matias da Rocha, Victor Alves Carneiro, Francisco Vassiliepe Sousa Arruda, Antônia Sâmia Fernandes do Nascimento, Nairley Cardoso Sá, Kyria Santiago Do Nascimento, Benildo Sousa Cavada, and Edson Holanda Teixeira. 2011. "Effect of Lectins from Diocleinae Subtribe against Oral Streptococci" Molecules 16, no. 5: 3530-3543. https://doi.org/10.3390/molecules16053530

APA Style

Cavalcante, T. T. A., Anderson Matias da Rocha, B., Alves Carneiro, V., Vassiliepe Sousa Arruda, F., Fernandes do Nascimento, A. S., Cardoso Sá, N., Do Nascimento, K. S., Sousa Cavada, B., & Holanda Teixeira, E. (2011). Effect of Lectins from Diocleinae Subtribe against Oral Streptococci. Molecules, 16(5), 3530-3543. https://doi.org/10.3390/molecules16053530

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