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• Prakash Chaturvedula, V
• Upreti, M
• Prakash, I
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• Upreti, M
• Prakash, I
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• Upreti, M
• Prakash, I

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Molecules 2011, 16(5), 3552-3562; doi:10.3390/molecules16053552

Article

Diterpene Glycosides from Stevia rebaudiana

Venkata Sai Prakash Chaturvedula* , Mani Upreti and Indra Prakash

The Coca-Cola Company, Organic Chemistry Department, Research and Technology, One Coca-Cola Plaza, Atlanta, GA 30313, USA

* Author to whom correspondence should be addressed.

Received: 24 March 2011; in revised form: 16 April 2011 / Accepted: 20 April 2011 / Published: 28 April 2011

(This article belongs to the Section Natural Products)

Download PDF Full-Text [278 KB, uploaded 28 April 2011 10:46 CEST]

Abstract: Three novel diterpene glycosides were isolated for the first time from the commercial extract of the leaves of Stevia rebaudiana, along with several known steviol glycosides, namely stevioside, rebaudiosides A-F, rubusoside and dulcoside A. The new compounds were identified as 13-[(2-O-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy] ent-kaur-15-en-19-oic acid (1), 13-[(2-O-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-16β-hydroxy-ent-kauran-19-oic acid (2) and 13-methyl-16-oxo-17-nor-ent-kauran-19-oic acid-β-D-glucopyranosyl ester (3) on the basis of extensive 2D NMR and MS spectroscopic data as well as chemical studies.

Keywords: Stevia rebaudiana; Compositae; Asteraceae; diterpenoid glycosides; spectral data; chemical studies

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