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Molecules 2011, 16(5), 3552-3562; doi:10.3390/molecules16053552

Diterpene Glycosides from Stevia rebaudiana

* ,  and
The Coca-Cola Company, Organic Chemistry Department, Research and Technology, One Coca-Cola Plaza, Atlanta, GA 30313, USA
* Author to whom correspondence should be addressed.
Received: 24 March 2011 / Revised: 16 April 2011 / Accepted: 20 April 2011 / Published: 28 April 2011
(This article belongs to the Section Metabolites)
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Three novel diterpene glycosides were isolated for the first time from the commercial extract of the leaves of Stevia rebaudiana, along with several known steviol glycosides, namely stevioside, rebaudiosides A-F, rubusoside and dulcoside A. The new compounds were identified as 13-[(2-O-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy] ent-kaur-15-en-19-oic acid (1), 13-[(2-O-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-16β-hydroxy-ent-kauran-19-oic acid (2) and 13-methyl-16-oxo-17-nor-ent-kauran-19-oic acid-β-D-glucopyranosyl ester (3) on the basis of extensive 2D NMR and MS spectroscopic data as well as chemical studies.
Keywords: Stevia rebaudiana; Compositae; Asteraceae; diterpenoid glycosides; spectral data; chemical studies Stevia rebaudiana; Compositae; Asteraceae; diterpenoid glycosides; spectral data; chemical studies
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prakash Chaturvedula, V.S.; Upreti, M.; Prakash, I. Diterpene Glycosides from Stevia rebaudiana. Molecules 2011, 16, 3552-3562.

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