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Molecules 2011, 16(5), 3519-3529; doi:10.3390/molecules16053519
Article

Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002

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Received: 29 March 2011; in revised form: 19 April 2011 / Accepted: 20 April 2011 / Published: 26 April 2011
(This article belongs to the collection Bioactive Compounds)
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Abstract: Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity. Two new polyenes were isolated from a culture broth of Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The structures of these compounds were determined to be α-pyrone-containing polyene analogues through analyses of HRFABMS, UV and NMR data, and were named Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA.
Keywords: Streptomyces; gombapyrone; α-pyrone; polyene Streptomyces; gombapyrone; α-pyrone; polyene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Park, H.B.; Yang, H.O.; Lee, K.R.; Kwon, H.C. Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002. Molecules 2011, 16, 3519-3529.

AMA Style

Park HB, Yang HO, Lee KR, Kwon HC. Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002. Molecules. 2011; 16(5):3519-3529.

Chicago/Turabian Style

Park, Hyun Bong; Yang, Hyun Ok; Lee, Kang Ro; Kwon, Hak Cheol. 2011. "Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002." Molecules 16, no. 5: 3519-3529.


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