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Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002
Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon-do 210-340, Korea
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea
* Author to whom correspondence should be addressed.
Received: 29 March 2011; in revised form: 19 April 2011 / Accepted: 20 April 2011 / Published: 26 April 2011
Abstract: Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity. Two new polyenes were isolated from a culture broth of Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The structures of these compounds were determined to be α-pyrone-containing polyene analogues through analyses of HRFABMS, UV and NMR data, and were named Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA.
Keywords: Streptomyces; gombapyrone; α-pyrone; polyene
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Park, H.B.; Yang, H.O.; Lee, K.R.; Kwon, H.C. Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002. Molecules 2011, 16, 3519-3529.
Park HB, Yang HO, Lee KR, Kwon HC. Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002. Molecules. 2011; 16(5):3519-3529.
Park, Hyun Bong; Yang, Hyun Ok; Lee, Kang Ro; Kwon, Hak Cheol. 2011. "Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002." Molecules 16, no. 5: 3519-3529.