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Molecules 2011, 16(4), 2971-2981; doi:10.3390/molecules16042971

Catalytic Enantioselective Aryl Transfer to Aldehydes Using Chiral 2,2’-Bispyrrolidine-Based Salan Ligands

1
School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China
2
School of Chemistry and Materials Science, Shanxi Normal University, Linfen, 041004, China
3
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China
4
School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of MOE, Nanjing University, Nanjing, 210093, China
*
Authors to whom correspondence should be addressed.
Received: 24 December 2010 / Revised: 15 March 2011 / Accepted: 16 March 2011 / Published: 6 April 2011
(This article belongs to the Special Issue Catalytic Asymmetric Synthesis)
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Abstract

Chiral C2-symmetric diamines have emerged as versatile auxiliaries or ligands in numerous asymmetric transformations. Chiral 2,2’-bispyrrolidine-based salan ligands were prepared and applied to the asymmetric aryl transfer to aldehydes with arylboronic acids as the source of transferable aryl groups. The corresponding diarylmethanols were obtained in high yields with moderate to good enantioselectivitives of up to 83% ee.
Keywords: 2,2’-bispyrrolidine; salan ligands; aryl transfer; arylboronic acid; enantioselectivity 2,2’-bispyrrolidine; salan ligands; aryl transfer; arylboronic acid; enantioselectivity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Jia, X.; Lin, A.; Mao, Z.; Zhu, C.; Cheng, Y. Catalytic Enantioselective Aryl Transfer to Aldehydes Using Chiral 2,2’-Bispyrrolidine-Based Salan Ligands. Molecules 2011, 16, 2971-2981.

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