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Molecules 2011, 16(3), 2688-2713; doi:10.3390/molecules16032688

Glycosides, Depression and Suicidal Behaviour: The Role of Glycoside-Linked Proteins

1
Department of Neuroscience, Mental Health and Sensory Functions, “Sapienza” University of Rome, Suicide Prevention Center, Sant’Andrea Hospital, Via Grottarossa 1035-1039, 00189 Rome, Italy
2
Villa Rosa, Scientific Medical Research Center, Suore Hospitaliere of the Sacred Heart of Jesus, 01100 Viterbo, Italy
3
McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
4
The Richard Stockton College of New Jersey, Jimmie Leeds Road, Pomona, NJ 08240, USA
5
Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Received: 17 December 2010 / Revised: 17 March 2011 / Accepted: 18 March 2011 / Published: 23 March 2011
(This article belongs to the Special Issue Glycosides)
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Abstract

Nowadays depression and suicide are two of the most important worldwide public health problems. Although their specific molecular mechanisms are still largely unknown, glycosides can play a fundamental role in their pathogenesis. These molecules act presumably through the up-regulation of plasticity-related proteins: probably they can have a presynaptic facilitatory effect, through the activation of several intracellular signaling pathways that include molecules like protein kinase A, Rap-1, cAMP, cADPR and G proteins. These proteins take part in a myriad of brain functions such as cell survival and synaptic plasticity. In depressed suicide victims, it has been found that their activity is strongly decreased, primarily in hippocampus and prefrontal cortex. These studies suggest that glycosides can regulate neuroprotection through Rap-1 and other molecules, and may play a crucial role in the pathophysiology of depression and suicide.
Keywords: glycosides; depression; suicidal behaviour; synaptic plasticity glycosides; depression; suicidal behaviour; synaptic plasticity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Serafini, G.; Pompili, M.; Innamorati, M.; Giordano, G.; Tatarelli, R.; Lester, D.; Girardi, P.; Dwivedi, Y. Glycosides, Depression and Suicidal Behaviour: The Role of Glycoside-Linked Proteins. Molecules 2011, 16, 2688-2713.

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