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Molecules 2011, 16(5), 3933-3968; doi:10.3390/molecules16053933
Review

Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview

*  and *
Received: 24 March 2011; in revised form: 18 April 2011 / Accepted: 20 April 2011 / Published: 10 May 2011
(This article belongs to the Special Issue Glycosides)
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Abstract: Uronic acids are carbohydrates present in relevant biologically active compounds. Most of the latter are glycosides or oligosaccharides linked by their anomeric carbon, so their synthesis requires glycoside-bond formation. The activation of this anomeric center remains difficult due to the presence of the electron-withdrawing C-5 carboxylic group. Herein we present an overview of glucuronidation, mannuronidation and galacturonidation reactions, including syntheses of prodrugs, oligosaccharides and stereochemical aspects.
Keywords: glycosidation; glucuronic acid; galacturonic acid; mannuronic acid; stereoselectivity glycosidation; glucuronic acid; galacturonic acid; mannuronic acid; stereoselectivity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wadouachi, A.; Kovensky, J. Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview. Molecules 2011, 16, 3933-3968.

AMA Style

Wadouachi A, Kovensky J. Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview. Molecules. 2011; 16(5):3933-3968.

Chicago/Turabian Style

Wadouachi, Anne; Kovensky, José. 2011. "Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview." Molecules 16, no. 5: 3933-3968.



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