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Glycosides, Depression and Suicidal Behaviour: The Role of Glycoside-Linked Proteins
Molecules 2011, 16(5), 3933-3968; doi:10.3390/molecules16053933
Review

Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview

*  and *
Laboratoire des Glucides UMR CNRS 6219, Université de Picardie Jules Verne, 33 Rue Saint Leu, F-80039 Amiens, France
* Authors to whom correspondence should be addressed.
Received: 24 March 2011 / Revised: 18 April 2011 / Accepted: 20 April 2011 / Published: 10 May 2011
(This article belongs to the Special Issue Glycosides)
Download PDF [472 KB, 18 June 2014; original version 18 June 2014]

Abstract

Uronic acids are carbohydrates present in relevant biologically active compounds. Most of the latter are glycosides or oligosaccharides linked by their anomeric carbon, so their synthesis requires glycoside-bond formation. The activation of this anomeric center remains difficult due to the presence of the electron-withdrawing C-5 carboxylic group. Herein we present an overview of glucuronidation, mannuronidation and galacturonidation reactions, including syntheses of prodrugs, oligosaccharides and stereochemical aspects.
Keywords: glycosidation; glucuronic acid; galacturonic acid; mannuronic acid; stereoselectivity glycosidation; glucuronic acid; galacturonic acid; mannuronic acid; stereoselectivity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wadouachi, A.; Kovensky, J. Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview. Molecules 2011, 16, 3933-3968.

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