Molecules 2011, 16(5), 3933-3968; doi:10.3390/molecules16053933
Review

Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview

Laboratoire des Glucides UMR CNRS 6219, Université de Picardie Jules Verne, 33 Rue Saint Leu, F-80039 Amiens, France
* Authors to whom correspondence should be addressed.
Received: 24 March 2011; in revised form: 18 April 2011 / Accepted: 20 April 2011 / Published: 10 May 2011
(This article belongs to the Special Issue Glycosides)
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Abstract: Uronic acids are carbohydrates present in relevant biologically active compounds. Most of the latter are glycosides or oligosaccharides linked by their anomeric carbon, so their synthesis requires glycoside-bond formation. The activation of this anomeric center remains difficult due to the presence of the electron-withdrawing C-5 carboxylic group. Herein we present an overview of glucuronidation, mannuronidation and galacturonidation reactions, including syntheses of prodrugs, oligosaccharides and stereochemical aspects.
Keywords: glycosidation; glucuronic acid; galacturonic acid; mannuronic acid; stereoselectivity

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MDPI and ACS Style

Wadouachi, A.; Kovensky, J. Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview. Molecules 2011, 16, 3933-3968.

AMA Style

Wadouachi A, Kovensky J. Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview. Molecules. 2011; 16(5):3933-3968.

Chicago/Turabian Style

Wadouachi, Anne; Kovensky, José. 2011. "Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview." Molecules 16, no. 5: 3933-3968.

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