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Molecules 2011, 16(3), 2259-2267; doi:10.3390/molecules16032259
Article

Diterpenoid Tanshinones and Phenolic Acids from Cultured Hairy Roots of Salvia miltiorrhiza Bunge and Their Antimicrobial Activities

1, 1, 1, 1, 2 and 1,*
1 College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China 2 Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
* Author to whom correspondence should be addressed.
Received: 13 January 2011 / Revised: 21 February 2011 / Accepted: 4 March 2011 / Published: 7 March 2011
(This article belongs to the collection Bioactive Compounds)
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Abstract

Four diterpenoid tanshinones and three phenolic acids were isolated from the crude ethanol extract of the cultured hairy roots of Salvia miltiorrhiza Bunge by bioassay-guided fractionation. By means of physicochemical and spectrometric analysis, they were identified as tanshinone ΙΙA (1), tanshinone Ι (2), cryptotanshinone (3), dihydrotanshinone Ι (4), rosmarinic acid (5), caffeic acid (6), and danshensu (7). These compounds were evaluated to show a broad antimicrobial spectrum of activity on test microorganisms including eight bacterial and one fungal species. Among the four tanshinones, cryptotanshinone (3) and dihydrotanshinone Ι (4) exhibited stronger antimicrobial activity than tanshinone ΙΙA (1) and tanshinone Ι (2). The results indicated that the major portion of the antimicrobial activity was due to the presence of tanshinones and phenolic acids in S. miltiorrhiza hairy roots, which could be used as the materials for producing antimicrobial agents for use in agricultural practice in the future.
Keywords: diterpenoid tanshinones; phenolic acids; cultured hairy roots; Salvia miltiorrhiza Bunge; antimicrobial activity diterpenoid tanshinones; phenolic acids; cultured hairy roots; Salvia miltiorrhiza Bunge; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhao, J.; Lou, J.; Mou, Y.; Li, P.; Wu, J.; Zhou, L. Diterpenoid Tanshinones and Phenolic Acids from Cultured Hairy Roots of Salvia miltiorrhiza Bunge and Their Antimicrobial Activities. Molecules 2011, 16, 2259-2267.

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