Molecules 2011, 16(3), 2253-2258; doi:10.3390/molecules16032253
Communication

In Vitro Cytotoxic Evaluation of a Novel Phosphinyl Derivative of Boldine

1email, 2email, 2email and 1,* email
Received: 10 January 2011; in revised form: 23 February 2011 / Accepted: 4 March 2011 / Published: 7 March 2011
(This article belongs to the Section Natural Products)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 2,9-Dimethoxymethylboldine (2), 2,9-dimethoxymethyl-3-bromoboldine (3) and 2,9-dimethoxymethyl-3-diphenylphosphinylboldine (4) have been synthesized in an effort to find compounds with potential pharmacological applications. The cytotoxic activities of the natural precursor 1 and these three derivatives have been measured as IC50 inhibitory growth. The diphenylphosphinyl derivative 4 showed a significant cytotoxic activity on two breast cancer cell lines, namely MCF-7 and MDA-MB-231, with IC50 values of 55.5 and 62.7 [µM], respectively. These results suggest that the kind of structural modifications introduced to synthesize compound 4 represent a promising way to enhance the cytotoxic activity of boldine derivatives.
Keywords: synthesis; phosphinyl derivative; boldine; cytotoxic activity
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MDPI and ACS Style

Thomet, F.A.; Piñol, P.; Villena, J.; Reveco, P.G. In Vitro Cytotoxic Evaluation of a Novel Phosphinyl Derivative of Boldine. Molecules 2011, 16, 2253-2258.

AMA Style

Thomet FA, Piñol P, Villena J, Reveco PG. In Vitro Cytotoxic Evaluation of a Novel Phosphinyl Derivative of Boldine. Molecules. 2011; 16(3):2253-2258.

Chicago/Turabian Style

Thomet, Franz A.; Piñol, Pablo; Villena, Joan; Reveco, Patricio G. 2011. "In Vitro Cytotoxic Evaluation of a Novel Phosphinyl Derivative of Boldine." Molecules 16, no. 3: 2253-2258.

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