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Molecules 2011, 16(3), 2146-2190; doi:10.3390/molecules16032146
Review

Antiplasmodial Natural Products

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Received: 25 January 2011 / Revised: 15 February 2011 / Accepted: 2 March 2011 / Published: 4 March 2011
(This article belongs to the Section Metabolites)
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Abstract

Malaria is a human infectious disease that is caused by four species of Plasmodium. It is responsible for more than 1 million deaths per year. Natural products contain a great variety of chemical structures and have been screened for antiplasmodial activity as potential sources of new antimalarial drugs. This review highlights studies on natural products with antimalarial and antiplasmodial activity reported in the literature from January 2009 to November 2010. A total of 360 antiplasmodial natural products comprised of terpenes, including iridoids, sesquiterpenes, diterpenes, terpenoid benzoquinones, steroids, quassinoids, limonoids, curcubitacins, and lanostanes; flavonoids; alkaloids; peptides; phenylalkanoids; xanthones; naphthopyrones; polyketides, including halenaquinones, peroxides, polyacetylenes, and resorcylic acids; depsidones; benzophenones; macrolides; and miscellaneous compounds, including halogenated compounds and chromenes are listed in this review.
Keywords: malaria; antimalarial; antiplasmodial; Plasmodium malaria; antimalarial; antiplasmodial; Plasmodium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nogueira, C.R.; Lopes, L.M.X. Antiplasmodial Natural Products. Molecules 2011, 16, 2146-2190.

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