Molecules 2011, 16(2), 1271-1296; doi:10.3390/molecules16021271
Review

Oligomeric Nucleic Acids as Antivirals

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Received: 20 December 2010; in revised form: 12 January 2011 / Accepted: 25 January 2011 / Published: 28 January 2011
(This article belongs to the Special Issue Antivirals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Based on the natural functions and chemical characteristics of nucleic acids, a variety of novel synthetic drugs and tools to explore biological systems have become available in recent years. To date, a great number of antisense oligonucleotides, RNA interference-based tools, CpG‑containing oligonucleotides, catalytic oligonucleotides, decoys and aptamers has been produced synthetically and applied successfully for understanding and manipulating biological processes and in clinical trials to treat a variety of diseases. Their versatility and potency make them equally suited candidates for fighting viral infections. Here, we describe the different types of nucleic acid-based antivirals, their mechanism of action, their advantages and limitations, and their future prospects.
Keywords: therapeutics; viruses; inhibition; viral replication; oligonucleotides  
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MDPI and ACS Style

Mescalchin, A.; Restle, T. Oligomeric Nucleic Acids as Antivirals. Molecules 2011, 16, 1271-1296.

AMA Style

Mescalchin A, Restle T. Oligomeric Nucleic Acids as Antivirals. Molecules. 2011; 16(2):1271-1296.

Chicago/Turabian Style

Mescalchin, Alessandra; Restle, Tobias. 2011. "Oligomeric Nucleic Acids as Antivirals." Molecules 16, no. 2: 1271-1296.

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