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Oligomeric Nucleic Acids as Antivirals
Institute of Molecular Medicine, University of Lübeck, Center for Structural and Cell Biology in Medicine (CSCM), Ratzeburger Allee 160, D-23538 Lübeck, Germany
* Author to whom correspondence should be addressed.
Received: 20 December 2010; in revised form: 12 January 2011 / Accepted: 25 January 2011 / Published: 28 January 2011
(This article belongs to the Special Issue Antivirals
Abstract: Based on the natural functions and chemical characteristics of nucleic acids, a variety of novel synthetic drugs and tools to explore biological systems have become available in recent years. To date, a great number of antisense oligonucleotides, RNA interference-based tools, CpG‑containing oligonucleotides, catalytic oligonucleotides, decoys and aptamers has been produced synthetically and applied successfully for understanding and manipulating biological processes and in clinical trials to treat a variety of diseases. Their versatility and potency make them equally suited candidates for fighting viral infections. Here, we describe the different types of nucleic acid-based antivirals, their mechanism of action, their advantages and limitations, and their future prospects.
Keywords: therapeutics; viruses; inhibition; viral replication; oligonucleotides
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Mescalchin, A.; Restle, T. Oligomeric Nucleic Acids as Antivirals. Molecules 2011, 16, 1271-1296.
Mescalchin A, Restle T. Oligomeric Nucleic Acids as Antivirals. Molecules. 2011; 16(2):1271-1296.
Mescalchin, Alessandra; Restle, Tobias. 2011. "Oligomeric Nucleic Acids as Antivirals." Molecules 16, no. 2: 1271-1296.