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Molecules 2011, 16(12), 10592-10603; doi:10.3390/molecules161210592
Article

Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves

1,2, 2,* , 3, 1, 1, 1 and 1,*
Received: 3 October 2011; in revised form: 23 November 2011 / Accepted: 2 December 2011 / Published: 19 December 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract: In this work, an evaluation of the biological activities of Globularia alypum L. extracts and their global chemical composition was realized. Extracts from G. alypum were obtained by two extraction methods. The composition of polyphenols (8.5–139.95 g gallic acid equivalent/Kg of dry mass), tannins (1.39–18.65 g catechin equivalent/Kg of dry mass), anthocyanins (8.17–70.69 mg cyanidin equivalent/Kg of dry mass) and flavonoids (0.31–19.28 g quercetin equivalent/Kg of dry mass) was evaluated. The samples were subjected to a screening for their antioxidant activities using the DPPH· and ABTS·+ assays. For the first time, the anti-tuberculosis activity (H37Rv) for G. alypum was tested against Mycobacterium tuberculosis. The strongest antioxidant activity was obtained for the methanol extract (IC50 = 15.58 ± 0.168 mg/L) and the best anti-tuberculosis activity was obtained for the petroleum ether extract (IC50 = 77 mg/L). We have found a positive correlation between the total phenolics content and the antioxidant activity R2 = 0.88 (DPPH·) and R2 = 0.97 (ABTS·+). We have found also a positive correlation between the flavonoid content and the antioxidant activity R2 = 0.91 (DPPH·) and R2 = 0.91 (ABTS·+).
Keywords: Globularia alypum L.; polyphenols; antioxidant activity; anti-tuberculosis activity Globularia alypum L.; polyphenols; antioxidant activity; anti-tuberculosis activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Khlifi, D.; Hamdi, M.; Hayouni, A.E.; Cazaux, S.; Souchard, J.P.; Couderc, F.; Bouajila, J. Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves. Molecules 2011, 16, 10592-10603.

AMA Style

Khlifi D, Hamdi M, Hayouni AE, Cazaux S, Souchard JP, Couderc F, Bouajila J. Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves. Molecules. 2011; 16(12):10592-10603.

Chicago/Turabian Style

Khlifi, Daycem; Hamdi, Moktar; Hayouni, Akrem El; Cazaux, Sylvie; Souchard, Jean Pierre; Couderc, François; Bouajila, Jalloul. 2011. "Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves." Molecules 16, no. 12: 10592-10603.


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