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Molecules 2011, 16(12), 10347-10356; doi:10.3390/molecules161210347
Article

Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery

1,†
, 2,†
, 3
, 4, 4,*  and 2,*
Received: 10 November 2011; in revised form: 25 November 2011 / Accepted: 5 December 2011 / Published: 14 December 2011
(This article belongs to the Section Metabolites)
Download PDF [254 KB, uploaded 18 June 2014]
Abstract: The purpose of this research was to prepare floating calcium alginate beads of berberine for targeting the gastric mucosa and prolonging their gastric residence time. The floating beads were prepared by suspending octodecanol and berberine in sodium alginate (SA) solution. The suspension was then dripped into a solution of calcium chloride. The hydrophobic and low-density octodecanol enhanced the sustained-release properties and floating ability of the beads. The bead formulation was optimized for different weight ratios of octodecanol and SA and evaluated in terms of diameter, floating ability and drug loading, entrapment and release. In vitro release studies showed that the floating and sustained release time were effectively increased in gastric media by addition of octodecanol. In vivo studies with rats showed that a significant increase in gastric residence time of beads had been achieved.
Keywords: berberine; octodecanol; calcium alginate beads; buoyancy; gastric residence berberine; octodecanol; calcium alginate beads; buoyancy; gastric residence
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, Z.-H.; Sun, Y.-S.; Pang, H.; Munyendo, W.L.; Lv, H.-X.; Zhu, S.-L. Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery. Molecules 2011, 16, 10347-10356.

AMA Style

Zhang Z-H, Sun Y-S, Pang H, Munyendo WL, Lv H-X, Zhu S-L. Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery. Molecules. 2011; 16(12):10347-10356.

Chicago/Turabian Style

Zhang, Zhen-Hai; Sun, Yong-Shun; Pang, Hui; Munyendo, Were L.L.; Lv, Hui-Xia; Zhu, Sheng-Liang. 2011. "Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery." Molecules 16, no. 12: 10347-10356.


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